Publications by authors named "Simona Altezza"
Article Synopsis
- The study introduces a novel unimolecular triagonist that combines insulin, GLP-1, and glucagon receptors for improved diabetes treatment and weight loss.
- The triagonist is created using alkyne-azide click chemistry, linking the insulin molecule with a coagonist peptide targeting GLP-1R and GCGR.
- The variations in the insulin conjugation sites were explored, with one specific triagonist showing promising activity comparable to current insulin treatments and effective receptor activities in animal models.
The MYC oncogene is upregulated in human cancers by translocation, amplification, and mutation of cellular pathways that regulate Myc. Myc/Max heterodimers bind to E box sequences in the promoter regions of genes and activate transcription. The MYC inhibitor Omomyc can reduce the ability of MYC to bind specific box sequences in promoters of MYC target genes by binding directly to E box sequences as demonstrated by romatin mmunorecipitation (CHIP).
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