Ruthenium-Catalyzed Selective Mono -Ethylation of Arylamines and Tandem Reduction/-Ethylation of Nitroarenes Using Triethylamine and Formic Acid.

The mono -alkylation of arylamines using alkylamines as alkyl group donors has been scarcely investigated. In this work, we report the mono -alkylation of several arylamines (52-95%) catalyzed by the complex ruthenium-triphos in the presence of Al(OTf). Moreover, the highly reductant ability of the catalyst system allows the tandem reduction/-alkylation of nitrobenzenes in good yields (up to 80%).

Natural pentacyclic triterpenoid as allosteric modulators of human 5-lipoxygenase with potential anti-inflammatory activity.

This study explored new methods to inhibit human 5-lipoxygenase (5-hLOX) by analyzing natural terpenes that share structural similarities with acetoxyboswellic acid (AKBA). Enzymatic assays were used to evaluate the terpene's ability to inhibit the enzyme, potentially providing anti-inflammatory benefits. Our research focused on how certain types of triterpenes can inhibit 5-hLOX allosterically a newly discovered allosteric site identified by enzyme crystallization.