Publications by authors named "Simon Steimle"
Article Synopsis
- * Noroxomaritidine reductase (NR) and Zt_SDR are SDRs with enhanced imine reduction potential compared to the keto-reducing Asparagus officinalis SDR (Ao_SDR), which has limited imine-reducing ability.
- * By modifying the active site of Ao_SDR and engineering another unrelated SDR (M77_SDR), researchers demonstrated that imine-reducing function can be introduced into SDRs
Lysine-specific demethylase 1 (LSD1) has evolved as a promising therapeutic target for cancer treatment, especially in acute myeloid leukaemia (AML). To approach the challenge of site-specific LSD1 inhibition, we developed an enzyme-prodrug system with the bacterial nitroreductase NfsB (NTR) that was expressed in the virally transfected AML cell line THP1-NTR . The cellular activity of the NTR was proven with a new luminescent NTR probe.
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