Workflow for the unsupervised clustering of sleep stages identifies light and deep sleep in electrophysiological recordings in mice.

Background: Sleep physiology plays a critical role in brain development and aging. Accurate sleep staging, which categorizes different sleep states, is fundamental for sleep physiology studies. Traditional methods for sleep staging rely on manual, rule-based scoring techniques, which limit their accuracy and adaptability.

Temporal trends in the treatment and outcomes of elderly patients with acute coronary syndrome.

Aims: To determine whether treatment and outcomes of older acute coronary syndrome (ACS) patients changed over time.

Methods And Results: We analysed the use of guideline-recommended therapies and in-hospital outcomes of 13 662 ACS patients ≥70 years enrolled in the prospective Acute Myocardial Infarction in Switzerland (AMIS) cohort between 2001 and 2012 according to 4-year periods (2001-2004, 2005-2008, and 2009-2012). Between first and last 4-year period, percutaneous coronary intervention (PCI) use increased from 43.

Acute coronary syndromes in young patients: presentation, treatment and outcome.

Background: Acute coronary syndromes (ACS) in very young patients have been poorly described. We therefore evaluate ACS in patients aged 35 years and younger.

Methods: In this prospective cohort study, 76 hospitals treating ACS in Switzerland enrolled 28,778 patients with ACS between January 1, 1997, and October 1, 2008.