An Objective Measurement of Lacunar Infarct Location from the Middle Cerebral Artery Stem.

Background: There is emerging interest in the relationship between neuroimaging location of lacunar infarcts and underlying stroke risk factors. Recent methods used for localization of lacunar infarcts are affected by high inter-rater variability. We used a novel algorithm-driven method that provided quantitative assessment of the distance of the lacunar infarct from the origins of the lenticulostriate arteries.

Comparison between site and central radiological assessments for patients with recurrent glioblastoma on a clinical trial.

Aim: Assessment of magnetic resonance imaging (MRI) in glioblastoma can be challenging. For patients with recurrent glioblastoma managed on the CABARET trial, we compared disease status assessed at hospitals and subsequent blinded central expert radiological review.

Methods: MRI results and clinical status at specified time points were used for site and central assessment of disease status.

Alterations in dorsal and ventral posterior cingulate connectivity in APOE 4 carriers at risk of Alzheimer's disease.

Background: Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns.

Aims: To examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein E (APOE 4) allele.

Method: Participants were 22 SMC carrying the APOE 4 allele (4+; mean age 72.

Imaging selection in ischemic stroke: feasibility of automated CT-perfusion analysis.

Background: Advanced imaging may refine patient selection for ischemic stroke treatment but delays to acquire and process the imaging have limited implementation.

Aims: We examined the feasibility of imaging selection in clinical practice using fully automated software in the EXTEND trial program.

Methods: CTP and perfusion-diffusion MRI data were processed using fully-automated software to generate a yes/no 'mismatch' classification that determined eligibility for trial therapies.