Systemic inflammation and health outcomes in patients receiving treatment for atherosclerotic cardiovascular disease.

Background And Aims: The burden and outcomes of inflammation in patients with atherosclerotic cardiovascular disease (ASCVD) are not well defined beyond the controlled settings of trials and research cohorts.

Methods: This was an observational study of ASCVD adults undergoing C-reactive protein testing in Stockholm's healthcare (2007-21). After excluding C-reactive protein tests associated with acute illness or medications/conditions that bias C-reactive protein interpretation, systemic inflammation was evaluated over a 3-month ascertainment window.

Education, employment, and income among people living with cystic fibrosis across three decades - A matched cohort study using Danish health registries.

Background: Past and ongoing advancements in cystic fibrosis (CF) care warrant long-term analysis of the societal impact of the condition. This study aims to evaluate changes in key socioeconomic factors across three decades among people living with CF (pwCF), compared with both the general population and an early-onset chronic disease population.

Methods: This nationwide, registry-based, matched cohort study included all pwCF ≥ 18 years in Denmark in the years 1990, 2000, 2010, and 2018.

100-mJ, 100-W cryogenically cooled Yb:YLF laser.

We present a diode-pumped Yb:YLF laser system generating 100-mJ sub-ps pulses at a 1-kHz repetition rate (100 W average power) by chirped-pulse amplification. The laser consists of a cryogenically cooled 78 K, regenerative, eight-pass booster amplifier seeded by an all-fiber front end. The output pulses are compressed to 980 fs in a single-grating Treacy compressor with a throughput of 89%.

Broadly tunable (993-1110 nm) Yb:YLF laser.

We have investigated room-temperature continuous-wave (cw) lasing performance of Yb:YLF oscillators in detail using rod-type crystals with low Yb-doping (2%). The laser is pumped by a low-cost, high brightness, 10 W, 960 nm single-emitter multimode diode. Laser performance is acquired in both // and // configurations, using 12 different output couplers with transmission ranging from 0.

Semiconductor saturable absorber mirror mode-locked Yb:YLF laser with pulses of 40 fs.

We have generated pulses as short as 40 fs with an average power of 265 mW from a semiconductor saturable absorber mirror (SESAM) mode-locked Yb:YLF oscillator employing a 1% transmitting output coupler (OC). The room-temperature laser is pumped by a low-cost 960 nm single-emitter multimode diode and dispersion compensation is provided via double chirped mirrors (DCMs). The 40-fs pulses are centered around 1050 nm with a width of 34 nm at a repetition rate of 87.

Positron emission tomography-computed tomography (PET-CT) in suspected malignant pleural effusion. An updated systematic review and meta-analysis.

The role of PET and integrated PET-CT in the diagnostic workup of suspected malignant pleural effusions is unknown. Earlier systematic reviews (published 2014 and 2015) both included pleural pathology without effusion, and reached contradictory conclusions. Five studies have been published since the latest review.

Mode-locked Cr:LiSAF laser far off the gain peak: tunable sub-200-fs pulses near 1 µm.

We report, to the best of our knowledge, the first mode-locking results of a Cr:LiSAF laser near the 1 µm region. The system is pumped only by a single 1.1 W high-brightness tapered diode laser at 675 nm.

Highly efficient cryogenic Yb:YLF regenerative amplifier with 250 W average power.

We report an efficient diode-pumped high-power cryogenic regenerative amplifier operating at 1019 nm employing the c axis of Yb:YLF. Compared to the usually selected 1017 nm transition of the a axis, the c-axis 1019 nm line has a three-fold higher emission cross section and still possesses a full-width at half-maximum (FWHM) of 6.5 nm at 125 K.

High power (>500W) cryogenically cooled Yb:YLF cw-oscillator operating at 995 nm and 1019 nm using E//c axis for lasing.

We present record continuous wave (cw) output power levels from cryogenically cooled Yb:YLiF (Yb:YLF) lasers in rod geometry. The laser system is pumped by a state-of-the-art 960 nm diode module, and vertically polarized lasing was employed using the E//c axis of Yb:YLF. Lasing performance was investigated at different output coupling levels in different cavity configurations and the laser crystal temperature was estimated via monitoring the emission spectrum of the gain media.

Diagnostic property of direct referral from general practitioners to contrast-enhanced thoracoabdominal CT in patients with serious but non-specific symptoms or signs of cancer: a retrospective cohort study on cancer prevalence after 12 months.

Objectives: To describe the diagnostic properties of thoracoabdominal contrast-enhanced CT (ceCT), when general practitioners (GPs) managed referral to ceCT through the non-specific symptoms or signs of cancer-cancer patient pathway (NSSC-CPP).

Design: Retrospective cohort study including patients from a part of Denmark.

Setting: Department of Internal Medicine at a university hospital.

Computed tomography of the chest in unilateral pleural effusions: outcome of the British Thoracic Society guideline.

Background: The guidelines from the British Thoracic Society (BTS) regarding the investigation of unilateral pleural effusions recommend computed tomography (CT) in exudates. We decided to investigate if clinicians follow BTS guidelines' recommendations with respect to CT in patients with unilateral pleural effusions. Secondly, to investigate the diagnostic consequences of following and not following this recommendation.

Incidence of malignancy and survival in patients with idiopathic pleuritis.

Background: The long-term outcome after non-diagnostic thoracoscopy (idiopathic pleuritis) has not been investigated in nationwide studies, and the survival has never been estimated. Therefore, we decided to investigate the three-year incidence of malignancy and survival of patients with idiopathic pleuritis.

Methods: Retrospective, register-based, nationwide study of patients undergoing diagnostic video-assisted thoracoscopic surgery (VATS) thoracoscopy ≤30 days after thoracentesis, using The National Patient Registry and The Danish Cancer Registry.

The value of computed tomography in discriminating malignant from non-malignant causes of unresolved unilateral pleural effusions: a systematic review.

The scientific background in expert-opinion papers for recommending Computed Tomography (CT) in unilateral pleural exudates is based on studies including patients with other findings than unilateral pleural effusions or selected patients undergoing thoracoscopy. Therefore, we performed a systematic review investigating the sensitivity of CT for predicting malignancy in patients with unilateral, non-transudative, pleural effusions. A search strategy was developed with the assistance of a medical information specialist at our university library.

Serum YKL-40 for monitoring myocardial ischemia after revascularization in patients with stable coronary artery disease.

Aim: The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD).

Methods: A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary intervention and after 6 months.

The influence of contrast media on kidney function in patients with stable coronary artery disease.

Aims: To investigate the incidence of contrast media-induced nephropathy (CIN) in patients with stable coronary artery disease (CAD) referred for elective coronary intervention following hydration routines. The reversibility of CIN was followed in a 6 month-period.

Methods And Results: A total of 447 patients referred for elective coronary intervention due to suspected CAD were included.