Genotypic and phenotypic variation in six patients with solitary median maxillary central incisor syndrome.

Solitary Median Maxillary Central Incisor occurs in 1 of 50,000 live births. It is the mildest manifestation of the holoprosencephaly spectrum and is genetically heterogeneous. Here we report six patients with solitary median maxillary central incisor, and a range of other phenotypic anomalies with different degrees of severity, varying from mild signs of holoprosencephaly to associated intellectual disability, and with different genetic background.

Cephalometric appraisal of post-treatment tooth eruption: a 20 year follow-up study.

Aim: To assess the amount of tooth eruption that occurs during 20 years after completion of orthodontic treatment and analyse possible correlations with age and mandibular growth pattern present.

Materials And Methods: A retrospective longitudinal cephalometric investigation of dento-alveolar changes was performed in 72 patients (50 women and 22 men). Two lateral cephalograms, taken at the end of orthodontic treatment and on average 20 years later, were available for each subject.