Baseline epitope-specific IgE profiles are predictive of sustained unresponsiveness or high threshold 1-year post oral immunotherapy in the POISED trial.

Background: Results from the POISED trial suggest that discontinuation of peanut oral immunotherapy can increase the risk of regaining clinical reactivity to peanut.

Objective: We sought to determine whether patients who achieved sustained unresponsiveness (SU) or sustained high threshold (SHT) have different baseline sequential epitope-specific IgE profiles than patients who achieved transient desensitization.

Methods: Subjects in the POISED trial (NCT02103270) were randomized to peanut (n = 95) or placebo (n = 25) for 24 months.

The meaning and value of taking part in a person-centred arts programme to hospital-based stroke patients: findings from a qualitative study.

Purpose: The importance of addressing mental well-being while stroke patients are in hospital has been recognized by policy makers but there is a gap between rhetoric and reality. This study explored the potential for using a person-centred, artist facilitated, one-to-one arts programme to improve the emotional and mental well-being of patients, which may be adversely affected as a result of the negative experiences arising from stroke and hospitalization.

Method: The study focused on those patients remaining in hospital for above average durations and included patients with functional, cognitive and speech or language impairments.