Publications by authors named "Simon M Mauvais"
Transfus Med Hemother
July 2018
Article Synopsis
- High-frequency blood group antigens (HFA) are found in over 90% of people, making it hard to find compatible blood for those who lack these antigens and may have alloantibodies.*
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- This study used high-throughput SNP genotyping on more than 37,000 Swiss blood donors to identify individuals with low-frequency blood group antigens (LFA).*
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- 326 potential donors with rare blood group genotypes were identified, highlighting the genetic diversity among Swiss donors influenced by regional and cultural factors.*
Br J Haematol
August 2016
Article Synopsis
- The study found that traditional genotyping methods for MNSs antigens struggle due to technical challenges arising from the similar gene sequences of GYPA, GYPB, and GYPE.
- Using MALDI-TOF MS, researchers identified eight MNSs-specific SNPs in a large sample of blood donors and achieved extremely high concordance and accuracy rates between serotyping and genotyping for M/N and S/s antigens.
- The research also assessed gene copy number variations using peak signal measurements, revealing new GYP*401 variants and suggesting potential for improved understanding of gene content variations, particularly in individuals of African descent.
