Publications by authors named "Simon Leekens"
Article Synopsis
- * Researchers created new dual-targeted In-radioconjugates that combine a prostate-specific membrane antigen (PSMA) inhibitor with a triphenyl phosphonium (TPP) group, enhancing uptake by prostate cancer cells and mitochondria.
- * The dual-targeted complexes show high stability, effective cell uptake, and reduced cell survival in cancer cells, offering potential for improved treatments using AE-emitting radionuclides, while also taking steps to explore other radiometals and optimize these constructs further.
Intermediate filaments (IFs) form an essential part of the metazoan cytoskeleton. Despite a long history of research, a proper understanding of their molecular architecture and assembly process is still lacking. IFs self-assemble from elongated dimers, which are defined by their central "rod" domain.
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