Publications by authors named "Simon Ledingham"
Article Synopsis
- A 68-year-old man had heart surgery to replace a valve but later had serious complications needing more surgery.*
- He faced another issue called a "trapped valve leaflet" that made his heart not work well.*
- Doctors used a new, less invasive method to fix the trapped leaflet, and he was able to go home 12 days later, showing hope for similar patients in the future.*
Article Synopsis
- Neutrophil activation post-cardiopulmonary bypass (CPB) can lead to lung complications, and this study investigates whether the healthy lung can modify pro-inflammatory neutrophils.
- Using a unique model involving bilateral pulmonary vein sampling during surgery, 17 patients undergoing coronary artery bypass grafting were analyzed to compare neutrophil function between ventilated and deflated lungs.
- Results showed no significant difference in neutrophil activity between samples from ventilated vs. deflated lungs, although plasma cytokines increased notably due to CPB.
Introduction: The incidence of postoperative thrombocytopenia after aortic valve replacement (AVR) with the Perceval S Sutureless bioprosthesis remains unclear. The aim of this study was to report thrombocytopenia associated with the use of sutureless AVR.
Methods: The data was collected retrospectively for patients who had isolated AVR with sutureless Perceval S valve (Group A: 72 patients) and was compared with patients who underwent isolated sutured AVR with Perimount Magna Ease Bioprosthesis (Group B: 101 patients) in our institution between June 2014 and January 2017.
Objective: The aim of this retrospective study was to compare early postoperative outcomes after aortic valve replacement (AVR) with sutureless bioprostheses and conventional stented bioprostheses implanted through median sternotomy.
Methods: From January 2011 to December 2016, 763 patients underwent aortic valve replacement with bioprostheses; of these, 139 received a Perceval S sutureless valve (Group A) and 624 received a Perimount Magna Ease valve (Group B). These groups were further divided into A1 (isolated Perceval AVR), A2 (Perceval AVR with coronary artery bypass grafting [CABG]), B1 (isolated conventional stented bioprosthesis), and B2 (conventional stented bioprosthesis + CABG).
Objective: The aim of this retrospective study is to evaluate the safety and performance of the Perceval sutureless valve in patients undergoing aortic valve replacement. We report the 30-day clinical outcomes of 139 patients.
Methods: From January 2014 to December 2016, 139 patients underwent sutureless aortic valve replacement.
Background: No-React treatment is known to render tissues resistant to calcific degeneration and to reduce early inflammatory response. No-React bovine internal mammary artery (NR-IMA) is available for restricted use in Europe. In this first study, our aim was to use magnetic resonance imaging (MRI) to investigate the clinical performance and patency rates of this conduit.
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