Publications by authors named "Simon K H Szeto"
Background: To investigate the impact of optic disc torsion (ODT), horizontal disc tilt (HDT) angle, and ovality index (OI) on different retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) segments in healthy myopic eyes.
Methods: ODT and OI were measured from fundus photographs. HDT angle, peripapillary RNFL, and macular GCIPL were measured by swept-source optical coherence tomography (SS-OCT).
Purpose: To evaluate the safety, efficacy, and imaging features of a novel surgical technique without endotamponade in repairing complex macular hole (MH).
Methods: Retrospective review of consecutive cases with complex MH underwent pars plana vitrectomy with temporal internal limiting membrane flap, which was stabilized using perfluorocarbon liquid and viscoelastics. At the conclusion of surgery, perfluorocarbon liquid was removed, and no endotamponade agent would be used.
Article Synopsis
- The study develops and tests deep learning models to assess the quality of 3D macular scans from two optical coherence tomography devices, Cirrus and Spectralis.
- Researchers collected and analyzed 3D scans from over 3,800 patients, and utilized a specialized deep learning network to classify scans as gradable or ungradable.
- The models demonstrated high accuracy in internal validation and external testing, indicating they could effectively filter out low-quality scans and be integrated with disease detection systems for automated eye disease diagnosis.
Article Synopsis
- Primary diabetes care and diabetic retinopathy (DR) screening face challenges due to a lack of trained primary care physicians, especially in low-resource areas.
- The integrated image-language system, DeepDR-LLM, combines a language model and deep learning to help PCPs provide tailored diabetes management recommendations, showing comparable or better accuracy than PCPs in diagnosing DR.
- In a study, patients assisted by DeepDR-LLM demonstrated improved self-management and adherence to referral recommendations, indicating that the system enhances both care quality and patient outcomes.
Introduction: The objective of this study was to compare the outcome of submacular hemorrhage (SMH) displacement using pneumatic displacement with intravitreal expansile gas versus pars plana vitrectomy (PPV) with subretinal injection of tissue plasminogen activator (tPA), anti-vascular endothelial growth factor (VEGF) agent, and air as primary surgery.
Methods: Retrospective interventional case series of 63 patients who underwent surgical displacement of SMH secondary to neovascular age-related macular degeneration (nAMD) or polypoidal choroidal vasculopathy (PCV) from May 1, 2015, to October 31, 2022. Medical records were reviewed for diagnosis, logMAR visual acuity (VA), central subfield thickness (CST), and postoperative displacement rates and complications up to 12 months after operation.
Article Synopsis
- Diabetic macular edema (DME) is a major cause of vision loss in diabetics, and this study assesses how effectively artificial intelligence (AI) can detect DME through fundus photography (FP) and optical coherence tomography (OCT) images.
- The analysis included 53 studies, revealing that AI models based on FP achieved an area under the curve (AUROC) of 0.964 with 92.6% sensitivity, while OCT-based models performed even better with an AUROC of 0.985 and 95.9% sensitivity.
- The study highlights the need for better external validation and larger, more diverse training datasets to enhance AI performance in detecting DME, pointing to factors like deep learning and sample
Article Synopsis
- * Researchers analyzed data from various clinical and animal studies, focusing on metrics like axial length elongation and progression of spherical equivalent refraction, to determine the effectiveness of each light wavelength.
- * Results indicated that red light was significantly more effective at slowing myopia progression compared to other wavelengths, both in overall clinical studies and when considering only randomized controlled trials.
A specific form of drusen, known as pachydrusen, has been demonstrated to be associated with pachychoroid eye diseases, such as central serous chorioretinopathy (CSC) and polypoidal choroidal vasculopathy (PCV). These pachydrusen have been found in up to 50% of eyes with CSC and PCV and may affect the disease progression and treatment response. This study aims to investigate the association between pachydrusen and changes in fundus autofluorescence (FAF) in eyes with CSC and PCV.
View Article and Find Full Text PDFOptical coherence tomography (OCT) is an invaluable imaging tool in detecting and assessing diabetic macular edema (DME). Over the past decade, there have been different proposed OCT-based classification systems for DME. In this review, we present an update of spectral-domain OCT (SDOCT)-based DME classifications over the past 5 years.
View Article and Find Full Text PDFGiant Fornix Syndrome: How Much Conjunctiva Should Be Resected?
Ophthalmic Plast Reconstr Surg
January 2022
Purpose: To characterize clinical profiles of Chinese patients with giant fornix syndrome (GFS), compare surgical outcomes with amount of Müller's muscle-conjunctival resection (MMCR), and elicit risk factors for those who have prolonged recovery after MMCR.
Methods: Retrospective, observational, interventional cohort study on GFS eyes. Two treatment groups were established: limited MMCR-as defined by 8 mm or less resection; maximal MMCR-as defined by 10-12 mm resection.
Purpose: To prospectively determine the relationship of OCT angiography (OCTA) metrics to diabetic retinopathy (DR) progression and development of diabetic macular edema (DME).
Design: Prospective, observational study.
Participants: A total of 205 eyes from 129 patients with diabetes mellitus followed up for at least 2 years.
Aims: To evaluate the performance of ultrawide field scanning laser ophthalmoscopy (UWF-SLO) for assessing diabetic retinopathy (DR) and diabetic macular oedema (DME) in a Chinese population, compared with clinical examination.
Methods: This is a retrospective cohort study. A series of 322 eyes from 164 patients with DM were included.
Purpose: To investigate the prevalence of ocular manifestations and visual outcomes in patients with herpes zoster ophthalmicus (HZO).
Methods: Consecutive cases diagnosed with HZO who attended 2 hospitals between July 1, 2011, and June 30, 2015, were retrospectively reviewed. Patient demographics, clinical presentations, and management were reviewed.