Quantifying energy expenditure in Göttingen Minipigs with the C-bicarbonate method under basal and drug-treated conditions.

Effective treatments of obesity focusing on energy expenditure (EE) are needed. To evaluate future EE-modulating drug candidates, appropriate animal models and methods to assess EE are needed. This study aimed to evaluate the stable isotope C-bicarbonate method (C-BM) for estimating EE in Göttingen minipigs under basal and drug-treated conditions.