Significantly contrasting solid state dynamics of the racemic and enantiomerically pure crystalline forms of an amino acid.

Solid state dynamic properties have been investigated for the racemic (DL) and enantiomerically pure (L) crystalline forms of the amino acid serine [HO x CH2 x CH(NH3(+)) x CO2(-)] using 2H NMR line shape analysis and 2H NMR spin-lattice relaxation time measurements for samples of DL-serine and L-serine deuterated in the NH3(+) and OH groups. 2H NMR line shape analysis indicates that, for both L-serine and DL-serine, the ND3(+) group undergoes a 3-site 120 degrees jump motion, with jump frequencies in the intermediate motion regime (10(3) s(-1) to 10(8) s(-1)) in the temperature range 153-313 K. However, at a given temperature, the jump frequency is substantially higher for L-serine (e.

Rationalizing the structural properties of bupivacaine base--a local anesthetic--directly from powder X-ray diffraction data.

Bupivacaine belongs to a family of 1-alkyl-2',6'-pipecoloxylidides, which has shown promise as reversible action potential blockers that can introduce prolonged local anesthetic effects. The crystal structure of the free-base form of bupivacaine has been determined directly from powder X-ray diffraction data using the Genetic Algorithm technique for structure solution, followed by Rietveld refinement. This work further emphasizes the scope and utility of ab initio structure solution directly from powder X-ray diffraction data for tackling structural problems within the biomedical field, leading to opportunities for the investigation of structure-property relationships.

Direct structure determination of a multicomponent molecular crystal prepared by a solid-state grinding procedure.

A three-component molecular cocrystal material has been prepared by a solvent-free route involving mechanical grinding of the pure phases of the individual components. This material is not accessible from conventional solution-state crystallization procedures. Due to the fact that the grinding procedure intrinsically leads to a microcrystalline powder sample, the use of powder X-ray diffraction data is essential for structure determination.

Ammonium cyanate shows N-H...N hydrogen bonding, not N-H...O.

The transformation of ammonium cyanate into urea, first studied over 170 years ago by Wöhler and Liebig, has an important place in the history of chemistry. To understand the nature of this solid state reaction, knowledge of the crystal structure of ammonium cyanate is a prerequisite. Employing neutron powder diffraction, we demonstrate conclusively that, in the structure of ammonium cyanate, the NH(4)(+) cation forms N-H.