Simplification Is Not Dominant in the Evolution of Chinese Characters.

Linguistic systems are hypothesised to be shaped by pressures towards communicative efficiency that drive processes of simplification. A longstanding illustration of this idea is the claim that Chinese characters have progressively simplified over time. Here we test this claim by analyzing a dataset with more than half a million images of Chinese characters spanning more than 3,000 years of recorded history.

The copy-number and varied strengths of MELT motifs in Spc105 balance the strength and responsiveness of the spindle assembly checkpoint.

During mitosis, the Spindle Assembly Checkpoint (SAC) maintains genome stability while also ensuring timely anaphase onset. To maintain genome stability, the SAC must be strong to delay anaphase even if just one chromosome is unattached, but for timely anaphase onset, it must promptly respond to silencing mechanisms. How the SAC meets these potentially antagonistic requirements is unclear.