Chronic pericarditis secondary to pericardial lymphangioma. An unusual presentation of an unusual tumor: case report.

Pericardial lymphangiomas are exceptionally rare and affect both children and adults. Although they are usually asymptomatic, they can cause symptoms secondary to the mass effect, from syncope or palpitations to arrhythmia or congestive heart failure. The most reliable diagnostic methods are echocardiography, computed tomography, and magnetic resonance imaging, with subsequent confirmation by histopathology.

An unusual case of gallstone ileus 35 years post-cholecystectomy masked by an incisional hernia.

Gallstone ileus is an uncommon cause of mechanical bowel obstruction in patients with cholecystitis and gallstones who develop a fistula over time. In the post-cholecystectomy patient, the presence of gallstone ileus is extremely rare; these patients have different pathophysiological pathways, such as a spilled gallstone that subsequently erodes into the bowel, subtotal cholecystectomies, and diverticulae that can hold a gallstone for hidden several years. In these patients, the clinical presentations are unique because of their rarity and because the gallbladder had been previously removed.

ECLIM-SEHOP: how to develop a platform to conduct academic trials for childhood cancer.

Introduction: ECLIM-SEHOP platform was created in 2017. Its main objective is to establish the infrastructure to allow Spanish participation into international academic collaborative clinical trials, observational studies, and registries in pediatric oncology. The aim of this manuscript is to describe the activity conducted by ECLIM-SEHOP since its creation.

Curation and expansion of Human Phenotype Ontology for defined groups of inborn errors of immunity.

Background: Accurate, detailed, and standardized phenotypic descriptions are essential to support diagnostic interpretation of genetic variants and to discover new diseases. The Human Phenotype Ontology (HPO), extensively used in rare disease research, provides a rich collection of vocabulary with standardized phenotypic descriptions in a hierarchical structure. However, to date, the use of HPO has not yet been widely implemented in the field of inborn errors of immunity (IEIs), mainly due to a lack of comprehensive IEI-related terms.

Phenotypic changes in calbindin D28K immunoreactivity in the hippocampus of Fmr1 knockout mice.

Fragile X syndrome (FXS), the most prevalent form of inherited mental retardation, is caused by the lack of FMRP (fragile mental retardation protein) as a result of the transcriptional silencing of the FMR1 gene. Here we analyze the immunohistochemical expression of the calbindin D28K protein in the hippocampus of Fmr1 knockout (KO) mice and compare it with that of their wildtype (WT) littermates. The spatial distribution pattern of calbindin-immunoreactive cells in the hippocampus was similar in WT and KO mice but for each age studied (ranging from 3.