Publications by authors named "Simon Grange"
Article Synopsis
- Pyomyositis, once common in tropical areas, is increasingly seen in temperate regions and among individuals with compromised immune systems, like those with HIV, cancer, or diabetes, as well as healthy athletes after minor injuries, making diagnosis difficult due to deep tissue involvement and vague symptoms.
- A 45-year-old woman presented with severe shoulder pain and restricted movement, initially misdiagnosed as a musculoskeletal strain until an MRI revealed an abscess in the subscapularis muscle, leading to multiple surgeries for drainage and treatment.
- The case emphasizes the need for awareness of pyomyositis in patients with significant shoulder pain, stressing timely diagnosis and interdisciplinary management for better patient outcomes, including surgery, antibiotics, and physical therapy
Article Synopsis
- Diverticular disease is becoming more common in Western countries, leading to complications such as perforated diverticulitis, which can occasionally cause severe infections.
- A case is presented of a 70-year-old man whose perforated sigmoid diverticulitis led to necrotizing fasciitis in his thigh and calf, requiring extensive surgical intervention.
- It's crucial for doctors to recognize the potential risks of diverticulitis and its complications, particularly for surgeons, as this awareness can significantly lower the chances of serious health issues.
Article Synopsis
- - The touch-screen-modified FRAX® tool was validated against a traditional healthcare provider-led questionnaire, showing high consistency in results from both patients and doctors, suggesting it can reliably assess osteoporosis fracture risk.
- - The study involved 50 patients over 50 years old, with a high completion rate of 88%, and results indicated excellent sensitivity and specificity for treatment recommendations and lifestyle advice, confirming the tool's effectiveness.
- - By implementing this self-assessment tool in outpatient clinics, the aim is to improve the identification of patients at risk for fractures while utilizing time that would otherwise be unproductive during patient wait times.
Article Synopsis
- The study examined how shoulder muscle coordination changes when wheelchair users propel on level ground versus an incline.
- Data was collected from seven nondisabled subjects using EMG recordings and kinetic measurements during propulsion on both a stationary ergometer and a ramp.
- Findings revealed increased push forces and changes in muscle activity patterns on inclines, suggesting that incline propulsion requires more intense use of push muscles and less use of recovery muscles, which can help inform better training methods for wheelchair users.
Patterns of shoulder muscle coordination vary between wheelchair propulsion techniques.
IEEE Trans Neural Syst Rehabil Eng
May 2014
Article Synopsis
- - The study analyzed how different wheelchair propulsion methods affect shoulder muscle coordination and wheelchair movements by comparing users' usual techniques with a taught semicircular method.
- - Data were collected on muscle activity and wheelchair performance, revealing that the semicircular technique resulted in lower push frequency and longer push length without increasing push force.
- - Results indicate that using the semicircular technique improves muscle coordination by clearly differentiating between push and recovery phases, suggesting its importance for newly injured wheelchair users.
Article Synopsis
- This study explored how the speed of wheelchair propulsion affects the muscle activation patterns of shoulder muscles using electromyography (EMG) and kinetic data from 15 nondisabled subjects.
- Significant differences in muscle activation were found between slower and faster speeds, with increased EMG intensity at higher speeds.
- Faster propulsion required not only enhanced activity from the muscles used for pushing but also earlier and more intense activation from recovery muscles.
Article Synopsis
- The study aimed to examine the effect of fatigue on muscle balance in manual wheelchair users (MWUs) to develop better activity strategies.
- It involved recording muscle activity (EMG) and kinetic data from participants as they propelled a wheelchair at two different speeds until they reached mild fatigue.
- Findings revealed that while endurance time didn't significantly affect kinetic variables, fatigue caused a notable increase in EMG intensity and muscle imbalance, suggesting the need for optimized propulsion techniques to prevent injury in MWUs.
Current issues and regulations in tendon regeneration and musculoskeletal repair with mesenchymal stem cells.
Curr Stem Cell Res Ther
March 2012
Article Synopsis
- - Mesenchymal stem cells are versatile cells found in connective tissues that can differentiate into various cell types, not just mesenchymal tissues like bone and fat, but also epithelial and nerve cells under certain conditions.
- - Their ability to adapt and influence the tissue environment by releasing substances is key to their role in tissue repair and regeneration, making them a promising option for therapeutic uses in soft tissue injuries.
- - While early clinical studies show promise for stem cell therapies, the integration of these treatments is complicated by regulatory changes and the need for proper oversight from both the scientific community and licensing bodies.
Article Synopsis
- The landscape of governance is evolving, emphasizing stricter regulations due to unpredictable side effects from new treatments, which places greater responsibility on researchers to protect study subjects while fostering innovation.
- The adoption of e-Governance is gaining traction in health research, particularly in policy-making, and is key for navigating regulations for advanced therapies like cell treatments in musculoskeletal science.
- Collaboration between technology developers and clinicians is crucial to ensure research adheres to EU directives and Human Tissue Authority regulations for the safe handling of human tissues and specimens.
Article Synopsis
- A digital archive is interconnected with its users and content, emphasizing the ongoing activities that support its purpose.
- The perspective on digital libraries is evolving from just being collections to focusing on the processes of collecting and sharing information.
- An advanced digital library environment has been created specifically for orthopaedic surgeons to link their experimental work with electronic publication of their findings.