First In Vivo and Phantom Imaging of Cyclotron-Produced La as a Theranostic Radionuclide for Ac and La.

Theranostic isotope pairs have gained recent clinical interest because they can be labeled to the same tracer and applied for diagnostic and therapeutic purposes. The goals of this study were to investigate cyclotron production of clinically relevant La activities using natural and isotopically enriched barium target material, compare fundamental PET phantom imaging characteristics of La with those of common PET radionuclides, and demonstrate in vivo preclinical PET tumor imaging using La-PSMA-I&T. La was produced on a 24-MeV cyclotron using an aluminum-indium sealed target with 150-200 mg of isotopically enriched BaCO, BaCO, and Ba metal.

Improved Sc-44 production in a siphon-style liquid target on a medical cyclotron.

In order to use new and promising radiometals for molecular imaging, it is important that they can be obtained as inexpensively and easily as possible. This often requires a cyclotron with solid target hardware or a radionuclide generator, which are not widely available for rarely used radionuclides. Here, we investigate the improved production of Sc with a siphon-style liquid target system and compare to our previous work with a simple liquid target.

High energy implementation of coil-target scheme for guided re-acceleration of laser-driven protons.

Developing compact ion accelerators using intense lasers is a very active area of research, motivated by a strong applicative potential in science, industry and healthcare. However, proposed applications in medical therapy, as well as in nuclear and particle physics demand a strict control of ion energy, as well as of the angular and spectral distribution of ion beam, beyond the intrinsic limitations of the several acceleration mechanisms explored so far. Here we report on the production of highly collimated ([Formula: see text] half angle divergence), high-charge (10s of pC) and quasi-monoenergetic proton beams up to [Formula: see text] 50 MeV, using a recently developed method based on helical coil targetry.

A comparative PET imaging study of Sc- and Ga-labeled bombesin antagonist BBN2 derivatives in breast and prostate cancer models.

Introduction: Radiolabeled peptides play a central role in nuclear medicine as radiotheranostics for targeted imaging and therapy of cancer. We have recently proposed the use of metabolically stabilized GRPR antagonist BBN2 for radiolabeling with F and Ga and subsequent PET imaging of GRPRs in prostate cancer. The present work studied the impact of Sc- and Ga-labeled DOTA complexes attached to GRPR antagonist BBN2 on the in vitro GRPR binding affinity, and their biodistribution and tumor uptake profiles in MCF7 breast and PC3 prostate cancer models.

Comparison of scandium-44 g with other PET radionuclides in pre-clinical PET phantom imaging.

Purpose: The decay characteristics of radionuclides in PET studies can impact image reconstruction. Sc has been the topic of recent research due to potential theranostic applications and is a promising radiometal for PET imaging. In this study, the reconstructed images from phantom measurements with scandium in a small-animal PET scanner are compared with F and two prominent radiometals: Cu and Ga METHODS: Three phantoms filled with F, C, Ga, and Sc were imaged in the Siemens Inveon PET scanner.

Modeling the pressure rise of a liquid target on a medical cyclotron: Steady-state analysis.

The steady-state behaviour of a liquid target used to produce medical isotopes by low-energy cyclotrons is studied. A model based on the conservation of mass and energy is proposed to describe the pressure rise of the target assuming equilibrium between liquid and vapour phases during irradiation. The effects of water radiolysis are taken into account.

(44g)Sc production using a water target on a 13MeV cyclotron.

Introduction: Access to promising radiometals as isotopes for novel molecular imaging agents requires that they are routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid target hardware, or to an isotope generator for the metal of interest is necessary, both of which can introduce significant hurdles in development of less common isotopes. Herein, we describe the production of ⁴⁴Sc (t1/2=3.