MSX1-expression during the different phases in healthy human endometrium.

Purpose: The human endometrium consists of different layers (basalis and functionalis) and undergoes different phases throughout the menstrual cycle. In a former paper, our research group was able to describe MSX1 as a positive prognosticator in endometrial carcinomas. The aim of this study was to examine the MSX1 expression in healthy endometrial tissue throughout the different phases to gain more insight on the mechanics of MSX-regulation in the female reproductive system.

MSX1-A Potential Marker for Uterus-Preserving Therapy of Endometrial Carcinomas.

Prognostic factors are of great interest in patients with endometrial cancer. One potential factor could be the protein MSX1, a transcription repressor, that has an inhibitory effect on the cell cycle. For this study, endometrioid endometrial carcinomas ( = 53), clear cell endometrial carcinomas ( = 6), endometrioid ovarian carcinomas ( = 19), and clear cell ovarian carcinomas ( = 11) were immunochemically stained for the protein MSX1 and evaluated using the immunoreactive score (IRS).