Publications by authors named "Simon D Roe"
Background: The purpose of this study was to report the evolution of coronary artery calcification (CAC) in subjects with chronic kidney disease Stages 3 and 4 comparing those with and without diabetes. We previously reported prevalence in the same population.
Methods: CAC was measured using multi-slice computer tomography.
Aim: Low vitamin D status is associated with secondary hyperparathyroidism and increased bone turnover in the general population and can aggravate the hyperparathyroidism of chronic kidney disease (CKD) patients. It is also correlated to low bone mineral density (BMD), but this correlation is less clear in CKD patients. Aims of our study were to investigate these associations in CKD stages 3 and 4 patients, and to identify significant predictors of BMD in this population.
View Article and Find Full Text PDFBackground: The purpose of this study was to describe the prevalence and extent of coronary artery calcification (CAC) in subjects with chronic kidney disease (CKD) stages 3 and 4 comparing those with and without diabetes. We also wished to determine if the presence of peripheral artery calcification (PAC) would assist in identifying patients positive for CAC.
Methods: CAC was detected by multi-slice computed tomography and PAC was detected by plain foot radiography.
Background: Osteoporosis is increasingly recognized as a major source of morbidity following renal transplantation. The aim of this cross-sectional study was to determine the prevalence of osteoporosis in a cohort of male transplant recipients and examine factors that may influence their bone loss.
Methods: Bone mineral density (BMD) and biochemical markers of bone metabolism were measured in 134 out of 154 male renal allograft recipients in our center.
Article Synopsis
- - The study examines how fragments of parathyroid hormone (PTH) can affect the accuracy of PTH tests and introduces a new assay that targets the PTH molecule more precisely, potentially avoiding false readings from these fragments.
- - It assessed PTH levels in serum samples from female renal transplant recipients classified with either hyperparathyroid or adynamic bone disease, using both 'whole molecule' and 'intact' PTH measurements.
- - Results showed that 'whole molecule' PTH levels were significantly lower than 'intact' PTH levels, but the assay didn't effectively differentiate between the two patient groups or provide significant extra clinical insights.