Reduced dengue incidence following city-wide wMel Wolbachia mosquito releases throughout three Colombian cities: Interrupted time series analysis and a prospective case-control study.

Background: The introduction of Wolbachia (wMel strain) into Aedes aegypti mosquitoes reduces their capacity to transmit dengue and other arboviruses. Randomised and non-randomised studies in multiple countries have shown significant reductions in dengue incidence following field releases of wMel-infected Ae. aegypti.

Large-scale releases and establishment of wMel Wolbachia in Aedes aegypti mosquitoes throughout the Cities of Bello, Medellín and Itagüí, Colombia.

Background: The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and has been shown to reduce the transmission of dengue and other Aedes-borne viruses. Here we report the entomological results from phased, large-scale releases of Wolbachia infected Ae. aegypti mosquitoes throughout three contiguous cities located in the Aburrá Valley, Colombia.

The impact of city-wide deployment of -carrying mosquitoes on arboviral disease incidence in Medellín and Bello, Colombia: study protocol for an interrupted time-series analysis and a test-negative design study.

Dengue, chikungunya and Zika are viral infections transmitted by mosquitoes, and present major public health challenges in tropical regions. Traditional vector control methods have been ineffective at halting disease transmission. The World Mosquito Program has developed a novel approach to arbovirus control using stably transfected with the bacterium, which have significantly reduced ability to transmit dengue, Zika and chikungunya in laboratory experiments.

Epidemiological, Serological, and Virological Features of Dengue in Nha Trang City, Vietnam.

Vietnam is endemic for dengue. We conducted a series of retrospective and prospective studies to characterize the epidemiology of dengue and population mobility patterns in Nha Trang city, Vietnam, with a view to rational design of trials of community-level interventions. A 10-year time series of dengue case notifications showed pronounced interannual variability, as well as spatial heterogeneity in ward-level dengue incidence (median annual coefficient of variation = 0.

Community-based control of Aedes aegypti by using Mesocyclops in southern Vietnam.

We previously reported a new community-based mosquito control strategy that resulted in elimination of Aedes aegypti (Linn.) in 40 of 46 communes in northern and central Vietnam, and with annual recurrent total costs (direct and indirect) of only $0.28-$0.

Abundance and prevalence of Aedes aegypti immatures and relationships with household water storage in rural areas in southern Viet Nam.

Since 2000, the Government of Viet Nam has committed to provide rural communities with increased access to safe water through a variety of household water supply schemes (wells, ferrocement tanks and jars) and piped water schemes. One possible, unintended consequence of these schemes is the concomitant increase in water containers that may serve as habitats for dengue mosquito immatures, principally Aedes aegypti. To assess these possible impacts we undertook detailed household surveys of Ae.

Householder perspectives and preferences on water storage and use, with reference to dengue, in the Mekong Delta, southern Vietnam.

Community-based perceptions and behaviour around water source preference, household water storage patterns and water use, and householders' knowledge and behaviour with respect to dengue etiology and transmission, were examined in three communes located in the Mekong Delta area in southern Vietnam. Through focus group discussions, most participants identified poorly screened or uncovered water containers (including household water storage containers and other types of artificial containers) as habitats for mosquitoes that transmit dengue viruses, and thereby demonstrated a clear understanding of the links between household water storage practices and the threat of dengue. Our qualitative analyses also revealed broader community-based concerns about the limited availability of water and strong preferences for storage of rainwater based upon perceptions of cost, quality and security of supply.