Publications by authors named "Simon Bm Lee"
Aim: Albuminuria progression has been associated with renal deterioration in type 2 diabetes (T2DM). Central arterial stiffness can aggravate systemic vasculopathy by propagating elevated systolic and pulse pressures forward, thereby accentuating global vascular injury. We aim to investigate whether central arterial stiffness is an independent predictor for albuminuria progression in a multi-ethnic T2DM Asian cohort in Singapore.
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- The study explores how inflammation relates to central arterial stiffness in Asian individuals with type 2 diabetes.
- Results showed that higher levels of high-sensitivity C-reactive protein correlated with increased arterial stiffness (measured by augmentation index), but not with pulse wave velocity.
- Conversely, higher levels of soluble receptor for advanced glycation end products were linked to a decrease in pulse wave velocity, indicating that inflammation may contribute to central arterial stiffness in this population.