Analytical solution for acoustic radiation force and torque on a spheroid near a rigid or free planar boundary.

An analytical solution is developed for the acoustic radiation force and torque caused by an arbitrary sound field that is incident on a compressible spheroid of any size near a planar boundary that is either rigid or pressure release. The analysis is an extension of a recent solution for a compressible sphere near a planar boundary [Simon and Hamilton, J. Acoust.

Analytical solution for acoustic radiation force on a sphere near a planar boundary.

Acoustic radiation force on a sphere in an inviscid fluid near a planar boundary, which may be rigid or pressure release, is calculated using spherical wave functions to expand the total pressure field. The condition at the boundary is satisfied with the addition of a reflected wave and an image sphere. The total pressure field, which is exact in the linear approximation, is composed of the incident field, the reflected field, and the scattered fields due to the physical sphere and the image sphere.

Evolution equation for nonlinear Lucassen waves, with application to a threshold phenomenon.

A nonlinear, fractional, surface wave equation with a spatial derivative of second order was developed by Kappler, Shrivastava, Schneider, and Netz [Phys. Rev. Fluids 2, 114804 (2017)] for propagation along an elastic interface coupled to a viscous incompressible liquid.

Inhibition of sodium-glucose cotransporter-2 preserves cardiac function during regional myocardial ischemia independent of alterations in myocardial substrate utilization.

The goal of the present study was to evaluate the effects of SGLT2i on cardiac contractile function, substrate utilization, and efficiency before and during regional myocardial ischemia/reperfusion injury in normal, metabolically healthy swine. Lean swine received placebo or canagliflozin (300 mg PO) 24 h prior to and the morning of an invasive physiologic study protocol. Hemodynamic and cardiac function measurements were obtained at baseline, during a 30-min complete occlusion of the circumflex coronary artery, and during a 2-h reperfusion period.

Let's talk about sex: gender norms and sexual health in English schools.

The sexual health of young people in England is an urgent public health concern. While interventions to address young people's sexual health have focussed on knowledge, skills and contraception access, amazingly none in the UK has explicitly addressed the effects of the social hierarchies of gender and gendered behavioural ideals that shape young people's sexual expectations, attitudes and behaviour. The lack of attention to gender is a persistent gap in health research, practice and policy.

Osteonecrosis following alcohol, cocaine, and steroid use.

Alcohol, steroids and cocaine have all been shown to be independent risk factors for osteonecrosis when taken in excess. Here we present a case of a young girl who developed debilitating osteonecrosis secondary to low doses of alcohol, steroids and cocaine. We feel it is important to highlight to those caring for such patients of the potential devastating complication of these three agents.

Sacral insufficiency fractures: an easily overlooked cause of back pain in the ED.

Sacral insufficiency fractures are an important and treatable cause of severe back pain. Despite publication of several case reports since its original description in 1982, awareness of these injuries remains inadequate in emergency medicine. Most patients are elderly women presenting with intractable lower back pain.

Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage.

Objective: Traumatic joint injury can damage cartilage and release inflammatory cytokines from adjacent joint tissue. The present study was undertaken to study the combined effects of compression injury, tumor necrosis factor alpha (TNFalpha), and interleukin-6 (IL-6) and its soluble receptor (sIL-6R) on immature bovine and adult human knee and ankle cartilage, using an in vitro model, and to test the hypothesis that endogenous IL-6 plays a role in proteoglycan loss caused by a combination of injury and TNFalpha.

Methods: Injured or uninjured cartilage disks were incubated with or without TNFalpha and/or IL-6/sIL-6R.

Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13.

Introduction: Fibronectin fragments have been found in the articular cartilage and synovial fluid of patients with osteoarthritis and rheumatoid arthritis. These matrix fragments can stimulate production of multiple mediators of matrix destruction, including various cytokines and metalloproteinases. The purpose of this study was to discover novel mediators of cartilage destruction using fibronectin fragments as a stimulus.

Parotid lymphomas--clinical and computed tomographic imaging features.

Objective: To review the clinical presentation and computed tomography (CT) imaging characteristics of all parotid lymphomas diagnosed at the study institution over a 7-year period.

Design: Retrospective chart review of parotid lymphomas diagnosed between 1997 and 2004.

Subjects: A total of 121 patients with parotid lesions were identified.

Azepanone-based inhibitors of human cathepsin L.

The extension of a previously reported cathepsin K azepanone-based inhibitor template to the design and synthesis of potent and selective inhibitors of the homologous cysteine protease cathepsin L is detailed. Structure-activity studies examining the effect of inhibitor selectivity as a function of the P3 and P2 binding elements of the potent cathepsin K inhibitor 1 revealed that incorporation of either a P3 quinoline-8-carboxamide or a naphthylene-1-carboxamide led to increased selectivity for cathepsin L over cathepsin K. Substitution of the P2 leucine of 1 with either a phenylalanine or a beta-naphthylalanine also resulted in an increased selectivity for cathepsin L over cathepsin K.

Extranodal lymphoma: clinical presentation and diagnostic pitfalls.

Non-Hodgkin's lymphomas (NHL) are known to present extranodally in 25% of cases, in contrast to Hodgkin's disease which rarely involves extranodal sites. In this article, the authors will to review the presentation of extranodal head and neck NHL and the difficulties that can be encountered in making the diagnosis in these cases.

What next for rheumatoid arthritis therapy?

Introduction of biological agents for the treatment of the chronic inflammatory joint disease rheumatoid arthritis has reinvigorated research into this debilitating disease. These agents have been shown to both act on the signs and symptoms of disease, as well as retard the progression of joint destruction. However, these agents are not efficacious in all cases and their expense and route of administration can severely limit their use.

Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines.

Objective: Traumatic joint injury leads to an increased risk of osteoarthritis (OA), but the progression to OA is not well understood. We undertook this study to measure aspects of proteoglycan (PG) degradation after in vitro injurious mechanical compression, including up-regulation of enzymatic degradative expression and cytokine-stimulated degradation.

Methods: Articular cartilage tissue explants were obtained from newborn bovine femoropatellar groove and from adult normal human donor knee and ankle tissue.

Small-molecule inhibitors of NF-kappaB for the treatment of inflammatory joint disease.

Recent advances in our understanding of the role of cytokine networks in inflammatory processes have led to the development of novel biological agents for the treatment of chronic inflammatory diseases. At the present time, significant efforts are focused on characterizing the complex signal transduction cascades that are activated by these cytokines and, in turn, regulate their expression. The transcription factor NF-kappaB is a pivotal regulator of the inducible expression of key proinflammatory mediators, and activated NF-kappaB has been observed in several debilitating inflammatory disorders, including rheumatoid arthritis and osteoarthritis.

Outcome analysis of patients with acute pancreatitis by using an artificial neural network.

Rationale And Objectives: The authors performed this study to evaluate the ability of an artificial neural network (ANN) that uses radiologic and laboratory data to predict the outcome in patients with acute pancreatitis.

Materials And Methods: An ANN was constructed with data from 92 patients with acute pancreatitis who underwent computed tomography (CT). Input nodes included clinical, laboratory, and CT data.