Ophthalmic acid as a read-out for hepatic glutathione metabolism in humans.

Background And Aim: Animal studies indicated that systemic ophthalmic acid (OPH) is a biomarker for hepatic glutathione (GSH) homeostasis, an important determinant of liver function. We aimed to clarify whether OPH levels can be used as a read-out for hepatic GSH homeostasis after paracetamol (APAP) challenges during pylorus-preserving pancreaticoduodenectomy (PPPD) or partial hepatectomy (PH).

Methods: Nineteen patients undergoing PPPD (n=7, control group) or PH (n=12) were included.

Percutaneous coronary intervention of an iatrogenic occlusion of the circumflex coronary artery after mitral valve replacement.

Occlusion of the circumflex coronary artery by compromising sutures is a serious complication in patients undergoing mitral valve replacement. The majority of such patients have to undergo bypass surgery or redo mitral valve replacement. We report a case of an iatrogenic occlusion of the circumflex coronary artery after mitral valve replacement that was treated by percutaneous coronary intervention.