Publications by authors named "Simon A M Kaeppeli"
Comparison of desferrioxamine and NODAGA for the gallium-68 labeling of exendin-4.
EJNMMI Radiopharm Chem
May 2019
Introduction: Radiolabeled exendin-4 (Ex4) derivatives are used to target the glucagon-like peptide-1 receptor (GLP-1R) for the clinical diagnosis of insulinomas, a rare type of neuroendocrine tumor. Gallium-68 is an ideal diagnostic nuclide for this application and a study evaluating an exendin-4-NODAGA conjugate is currently underway. However, in complexion with the chelator DFO, its in vivo stability has been a matter of dispute.
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- The glucagon-like peptide-1 receptor (GLP-1R) is crucial for glucose metabolism and is highly present on pancreatic β-cells, making it relevant for diseases like diabetes and insulinomas.
- Radiolabeled exendin-4, used for imaging insulinomas, has a significant issue with high kidney accumulation, prompting the investigation of modifications to improve its safety and efficacy.
- By attaching an albumin-binding moiety (ABM) to exendin-4, researchers achieved lower kidney uptake while maintaining receptor affinity, resulting in better diagnostic imaging for insulinomas and potentially GLP-1R-positive tissues.