Sex-Specific Variations in Vitamin D and Vitamin D Binding Protein (Vdbp) and Flipped Pattern of their Association in Preeclamptic Women with Dyslipidemia.

Background: Women with preeclampsia frequently have disorders of calcium metabolism during their pregnancies, including hypocalciuria and low vitamin D levels. The link between fetal sex and vitamin D and vitamin D binding protein levels in pregnancy and preeclampsia is not clear.

Aim: Present study was designed to explore sex-specific variations in vitamin D and vitamin D binding protein levels in maternal and umbilical cord blood samples for age and gestation matched 20 primigravida normotensive and 20 primigravida with preeclampsia with a singleton pregnancy.

Multi-omics and machine learning for the prevention and management of female reproductive health.

Females typically carry most of the burden of reproduction in mammals. In humans, this burden is exacerbated further, as the evolutionary advantage of a large and complex human brain came at a great cost of women's reproductive health. Pregnancy thus became a highly demanding phase in a woman's life cycle both physically and emotionally and therefore needs monitoring to assure an optimal outcome.

Comparative Evaluation of Serum High-sensitivity C-Reactive Protein and Complete Hemogram Indices in Subjects with and without Apical Periodontitis: A Prospective Interventional Study.

Introduction: This study aimed to compare the levels of high-sensitivity C-reactive protein (hsCRP) and complete hemogram (CH) parameters before and after root canal treatment in patients with apical periodontitis (AP) and healthy controls.

Methods: Twenty-five patients with asymptomatic AP in a single permanent tooth were recruited along with age- and sex-matched healthy controls. Baseline serum hsCRP and CH parameters were recorded in both groups.

Heme oxygenase-1 in osteosarcoma.

Aim Of Study: The present study was planned to analyze serum heme oxygenase-1 levels in osteosarcoma patients.

Materials And Methods: Twenty five histopathologically confirmed cases of osteosarcoma localized without metastasis of all the ages attending the Orthopedic Clinics were included in the study group and twenty five patients having musculoskeletal pain (age and sex matched) served as control. Five ml of venous blood was collected aseptically from antecubital vein and serum was be separated by centrifugation and analyzed the same day.

Serum iron, Folate, Ferritin and CD4 Count in HIV Seropositive Women.

HIV infects cluster of differentiation 4 (CD4) T-lymphocytes, monocytes and macrophages resulting in decreased number and function of CD4 cells, changes that affect both cell mediated and humoral immunity. Hematological abnormalities are a common complication of human immune virus (HIV) infection and these abnormalities increase as the disease advances. Anemia is the most common haematological abnormality in HIV seropositive patients and its incidence is strongly associated with the progression of the disease.

Evaluation of Homocysteine, Vitamin B12 and Folic Acid Levels During all the Trimesters in Pregnant and Preeclamptic Womens.

Background: Folate, vitamin B12 and vitamin B6 are required for homocysteine metabolism and their deficiency can result in increased homocysteine concentration. Homocysteine concentrations have been found to be increased in late pregnancy toward nonpregnant values.

Objective: To study folate, vitamin B12 and homocysteine levels in cord blood and maternal blood in preeclampsia.

Biomarkers in Preeclamptic Women with Normoglycemia and Hyperglycemia.

The present study was planned to assess IGF-1, leptin and cholinesterase levels in maternal blood of both normoglycaemics and hyperglycaemics preeclampsia. Twenty five normotensive pregnant women at the time of delivery were selected in as group I and sub grouped according to blood glucose less than or more than 85 mg/dL as I A (<85mg/dL) and I B (>85mg/dL). Study group (group II, n=25) comprised of preeclamptic women and was further divided into group II A (<85mg/dL) and group II B (>85mg/dL).

Homocysteine, a biomarker of osteosarcoma.

Aim Of Study: The present study was planned to analyze the status of serum homocysteine (hcy), folate, and Vitamin B 12 in patients with osteosarcoma.

Materials And Methods: The present study was conducted on 60 orthopedics patients who were divided into two groups, group I with 30 patients of osteosarcoma and group II with 30 patients with musculoskeletal pain.

Results: The present study indicated that serum folate and hcy levels were increased in osteosarcoma patients and decreased Vitamin B 12 in osteosarcoma patients when compared to controls.

Plasma malondialdehyde (MDA) and anti-oxidant status in diabetic retinopathy.

Hyperglycaemia and dyslipidaemia in diabetes mellitus induce increased lipid peroxidation and peroxyl radical formation is an important mechanism in genesis of micro-angiopathy. We took up a study on oxidative stress as measured by lipid peroxidation marker, malondialdehyde (MDA) and antioxidant enzyme status in type 2 diabetes mellitus patients with and without retinopathy and compared them with a control non-diabetic group. MDA was significantly elevated (p < 0.

Fluoride levels and osteosarcoma.

Context: Osteosarcoma is a rare malignant bone tumor, commonly occurring in the age group of 10 to 24 years. Recent reports have indicated that there is a link between fluoride exposure and osteosarcoma.

Aims: The present study was planned to analyze serum levels of fluoride in patients of osteosarcoma and fluoride content of their drinking water.

Birth weight, cord blood lipoprotein and apolipoprotein levels in Indian newborns.

Objectives: Primordial prevention of chronic disease is of clinical and public health importance. Considering the fetal onset of atherosclerosis, we aimed to determine the cord blood level of lipoproteins and apolipoproteins as well as their correlation with birth weight and gestational age.

Methods: This cross-sectional study comprised 100 healthy Indian newborns.

Serum markers in pre-eclampsia.

Preeclampsia occurs approximately in 10% of pregnancies and remains a leading cause of maternal and neonatal mortality and morbidity worldwide, particularly in developing countries. The condition is usually diagnosed in late pregnancy by the presence of hypertension with proteinuria and/ or edema. Prevention of any disease process requires knowledge of its etiology and pathogenesis, as well as the availability of methods for prediction of those at high risk for this disorder.

Thyroid hormones in pregnancy and preeclampsia.

Objective: There is a state of hypothyroxinemia in normal pregnancy and in preeclampsia, when biochemically raised TSH occurs. Identification of changes in thyroid hormones in preeclampsia might be of help in preventing the occurrence of preeclampsia.

Material And Methods: The present study was carried out in a hundred women with preeclampsia, 100 age- and parity matched normotensive pregnant women and 50 age-matched healthy non-pregnant women.

Biomarkers of periodontitis in oral fluids.

Matrix metalloproteinases (MMPs), the key enzymes responsible for matrix degradation, are derived from polymorphonuclear leukocytes during the early stages of periodontitis. The present study determined the levels of GCF matrix metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9) and salivary MMP-8 in patients with gingivitis and periodontitis and in healthy controls. Levels of crevicular MMP-2, MMP-9 and salivary MMP-8 were determined by ELISA in subjects with healthy gingiva (n = 15), gingivitis (n = 18) and periodontitis (n = 20).

Salivary vitamins E and C in oral cancer.

Lipid peroxidation may be involved in cancer and essential nutrients that can scavenge free radicals, such as vitamins E and C, operate in concert. Levels of antioxidant vitamins E and C were estimated in 50 patients with oral cancer and 24 healthy persons served as control. Significantly lower levels of vitamins E and C were observed in oral cancer patients as compared to controls (P < 0.

Plasma tocopherol levels: a preliminary reference range.

Alpha-tocopherol level was measured spectrofluorometrically in 279 healthy volunteers to establish reliable reference values and to compare possible sex and age-related differences. In the present study, men had higher tocopherol levels than women (p<0.05) and older subjects had lower values.

Antioxidant status in neonatal jaundice before and after phototherapy.

Phototherapy has been related to increased oxidative stress and lipid peroxidation. In the present study, thirty full term jaundiced neonates with appropriate weight were analyzed before and after completion of phototherapy for malondialdehyde (MDA), reduced glutathione (GSH), total thiols, vitamin C and superoxide dismutase (SOD) levels in hemolysate and albumin levels in plasma. These parameters were analyzed in cord blood samples of 20 healthy neonates as control.

Nutriceuticals in health and disease prevention.

Available evidence suggests that we can not dismiss the potential value of nutriceuticals in disease and inhibition of atherosclerosis. Epidemiologic data suggest that antioxidant supplementation may be associated with a reduced risk of clinical events from atherosclerosis; howere, interventional trials only support a role for vitamin E in this regard. Many studies suggest that a link between fruit and vegetables in diet or the amounts of plasma antioxidant vitamins (ascorbic acid, tocopherols and carotenoids) and risk of death from cancer or coronary heart disease.

Plasma lipoperoxides: a preliminary reference range.

We measured lipoperoxides, as malonaldehyde (MDA) by thiobarbituric acid reaction in serum from 80 male and 120 female volunteers to establish reliable reference values and to compare possible sex- and age- related differences. In the present study women had higher MDA concentration in serum than do men (p<0.05) and older subjects had higher values (p<0.

Serum biochemical markers in carcinoma breast.

Background: Despite the extensive research for many years throughout the world, the etiopathogenesis of cancer still remains obscure. For the early detection of carcinoma of various origins, a number of biochemical markers have been studied to evaluate the malignancy.

Aim: To analyse serum gamma glutamyl transpeptidase (GGTP), lactate dehydrogenase (LDH) and superoxide dismutase (SOD) in carcinoma breast patients.

Low blood glutathione levels in acute myocardial infarction.

Background: Although experimental studies have demonstrated that reduced glutathione (GSH) is involved in cellular protection from deleterious effects of oxygen free radicals in ischaemia and reperfusion, there are controversial data on the correlation between levels of GSH and the ischaemic process.

Aim: The present study was planned to evaluate erythrocyte GSH levels in patients with acute myocardial infarction (AMI).

Setting & Design: Erythrocyte GSH levels were determined in 22 patients with AMI and 15 age matched healthy volunteers served as control.