Swallowing sound evaluation using an electronic stethoscope and artificial intelligence analysis for patients with amyotrophic lateral sclerosis.

Background And Purpose: Non-invasive, simple, and repetitive swallowing evaluation is required to prevent aspiration pneumonia in neurological care. We investigated the usefulness of swallowing sound evaluation in patients with amyotrophic lateral sclerosis (ALS) using our new electronic stethoscope artificial intelligence (AI) analysis tool.

Methods: We studied patients with ALS who provided written informed consent.

Endovascular Treatment of Carotid Blowout Syndrome.

Background: Carotid blowout syndrome (CBS) is a life-threatening disease characterized by compromise of the carotid artery by head and neck cancer (HNC).

Materials And Methods: We reviewed the characteristics and outcomes of all patients with carotid blowout syndrome who were treated between April 2010 and December 2019. Twelve patients with a history of HNC and radiation therapy were investigated.

Morphological reproductive characteristics of testes and fertilization capacity of cryopreserved sperm after the Fukushima accident in raccoon (Procyon lotor).

Since the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident, we have established an archive system of livestock and wild animals from the surrounding ex-evacuation zone. Wildlife within the alert zone have been exposed to low-dose-rate (LDR) radiation for a long continuous time. In this study, we analysed the morphological characteristics of the testes and in vitro fertilization (IVF) capacity of cryopreserved sperm of racoons from the ex-evacuation zone of the FDNPP accident.

[Case report of transient splenium abnormality in Charcot-Marie-Tooth disease].

We report a patient of Charcot-Marie-Tooth disease (CMT) accompanied by transient splenium abnormality in brain MRI. A 34-year-old man suffered from chronic progressive unsteadiness and sensory disturbance of all limbs. Neurological examination showed muscle weakness and atrophy in the distal extremities with pes cavus, mild sensory disturbance of four extremities and generalized decreased reflexes.

Successful long-term control with lamivudine against reactivated hepatitis B infection following intensive chemotherapy and autologous peripheral blood stem cell transplantation in non-Hodgkin's lymphoma: experience of 2 cases.

It is well documented that cytotoxic treatment in patients carrying the hepatitis B virus (HBV) enhances the risk of severe hepatic damage. Recently lamivudine has been reported to be effective in suppressing the replication of HBV under such conditions. Here we report two cases with HBV carrier status and with non-Hodgkin's lymphoma who were successfully treated with high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation with the administration of lamivudine to prevent HBV flare-up.

Microsomal casein kinase II in endoplasmic reticulum- and Golgi apparatus-rich fractions of ROS 17/2.8 osteoblast-like cells: an enzyme that modifies osteopontin.

Osteopontin is an acidic phosphoprotein containing casein kinase II (CKII) phosphorylatable sites and an acidic amino acid cluster. The metabolically 32P-labelings of both serines and threonines in vitro in osteopontin immunoprecipitated from rat osteoblast-like ROS 17/2.8 cells may suggest that casein kinase II catalyzes this modification.

[Results of emergency coronary artery bypass surgery after failed coronary angioplasty].

In the past 7 years, 9 emergent or urgent coronary artery bypass operations after failed percutaneous transluminal angioplasty (PTCA) were performed among 947 (PTCA). Since the introduction of coronary perfusion catheter system for the support of coronary perfusion during PTCA we could reduce the number of emergent cases and these patients could be operated on semi-emergently and securely without endangering co-medical staffs in a hurry. It is also unnecessary to be on standby all the time when the PTCA is being undertaken.

[Study of metabolism of T-3761 in animal].

The metabolism of T-3761 in mouse, rat, rabbit, dog and monkey was studied. Four metabolites, other than unchanged T-3761, were detected and identified as follows: T-3761 glucuronide; T-3761M1, adduct of glucose; T-3761M2 and T-3761M3, compounds metabolized at 1-aminocyclopropyl ring. In urine of mouse, T-3761 glucuronide was mainly detected, but in urine of other animals, T-3761 was mainly detected.

[Determination of T-3761 in body fluids by high-performance liquid chromatography].

A high-performance liquid chromatographic procedure was developed for determination of T-3761 in human serum and urine. The method was based on column switching for serum, and direct injection for urine. The peaks were monitored by ultraviolet detection.

[Clinical evaluation of endoscopic ultrasonography (EUS) in the diagnosis of superficial esophageal carcinoma].

Pre-operative diagnosis of the depth of invasion is important to decide the treatment of superficial esophageal carcinoma. The ability of EUS to diagnose the depth of invasion was examined in 40 lesions with superficial esophageal carcinoma between January 1993 and April 1994. The depth of invasion was classified as m1 or m2, m3 or sm1, and sm2 or more.

[Comparative analysis of living conditions of elderly diabetic patients in rural areas].

The present study was performed to examine living conditions of elderly diabetic patients in rural areas in Iwate and Miyagi in northern Honsyu and compared them with similar cases in Tokyo. One hundred and nine cases over 60 years old were interviewed, and results were compared to 109 age- and sex-matched random samples in the Tokyo area. The original Tokyo subjects consisted of 383 outpatients of the Diabetic Clinic of Tokyo Metropolitan Geriatric Hospital.

A case of dilated cardiomyopathy manifested by exercise-induced left bundle branch block.

We report an extremely rare case of dilated cardiomyopathy manifested by exercise-induced left bundle branch block. A 63-year-old female came to our hospital because supraventricular arrhythmia had been detected at a check-up. A treadmill exercise test induced left bundle branch block.

[Pulmonary nodule confirmed by rib consolidation on thoracic computed tomography].

Coin lesions in the thoracic cavity, skin, muscle and connective tissue are clearly observed by computed tomography (CT). However, it is very difficult to detect abnormal shadows in the ribs by thoracic CT at the mediastinal level. We describe 3 cases of pulmonary nodules that were not detected by CT at the mediastinal or lung field level, however, but could be detected at the bone level.

[Pyeloureteritis cystica: report of a case].

A 68-year-old female patient was admitted for the examination of duplication of right ureter and right hydronephrosis. Antegrade pyelography showed multiple, small, round defects in the ureter from the upper pole of right kidney. Ureteroureterostomy was performed under the diagnosis of ureteritis.

Characterization of immunoglobulin A antibody in serum of swine inoculated with transmissible gastroenteritis virus.

Sera and contents of the small intestine from swine inoculated with transmissible gastroenteritis (TGE) virus were examined for immunoglobulin (Ig) A antibody responses by the radioimmunoprecipitation test with antiporcine IgA serum. When swine were orally inoculated with virulent virus, IgA antibody activity was detected in the contents of the small intestine and in serum from postinoculation days 7 to 56. However, IgA antibody activity was not detected in the contents of the small intestine or serum in swine inoculated IM with attenuated virus.