Pathways From Socioeconomic Factors to Major Cardiovascular Events Among Postmenopausal Veteran and Nonveteran Women: Findings From the Women's Health Initiative.

Background: Cardiovascular disease (CVD) remains a leading cause of death for women in the United States, with veterans being at potentially higher risk than their nonveteran counterparts due to accelerated aging and distinct biopsychosocial mechanisms. We examined pathways between selected indicators of socioeconomic status (SES) such as education, occupation, household income, and neighborhood SES and major CVD events through lifestyle and health characteristics among veteran and nonveteran postmenopausal women.

Methods And Results: A total of 121 286 study-eligible WHI (Women's Health Initiative) participants (3091 veterans and 118 195 nonveterans) were prospectively followed for an average of 17 years, during which 16 108 major CVD events were documented.

Parental democratic communication and adolescent well-being in an era of loneliness: the mediating role of societal trust.

Background: In an era marked by increasing loneliness, understanding the impact of parenting practices on adolescent well-being and resilience is crucial. This study investigates the relationship between parental democratic communication and key indicators of adolescent adjustment and well-being in China, with a focus on the mediating role of societal trust.

Objective: The study aimed to examine the direct effects of parental democratic communication on Chinese adolescents' subjective well-being and to explore the mediating roles of societal trust in this relationship.

A supramolecular diazapyrene radical assembly with NIR absorption for selective photothermal antibacterial activity.

A supramolecular radical assembly that can be induced by facultative anaerobic bacteria has been reported and used for selective near-infrared (NIR) photothermal antibacterial action. Herein, we report the synthesis of a water-soluble diazapyrene derivative (DAPNP), which could be initiated into the corresponding radicals by facultative anaerobic bacteria, such as or . The introduction of cucurbit[10]uril (CB[10]) alters the stacking mode of the diazapyrene radical cations, resulting in a redshift of their characteristic absorption peak from the visible region to the NIR region.

Performance Evaluation of Pebble Concrete for Pavement: A Study on the Sucre Highway Project.

Bolivia has abundant pebbles, while the supply of crushed stone is limited and unstable. Thus, the resource utilization of local pebble as a coarse aggregate and the guarantee of concrete durability are the key scientific issues in the Sucre Highway Project. In this paper, a comparative analysis was conducted of the performance of crushed stone concrete and pebble concrete.

Association between sarcopenia and osteoporosis: the cross-sectional study from NHANES 1999-2020 and a bi-directions Mendelian randomization study.

Background: Osteoporosis (OP) and sarcopenia are prevalent musculoskeletal conditions among the elderly. Nevertheless, the causal relationship between sarcopenia and OP remains a subject of controversy and uncertainty. In this study, we employed cross-sectional analysis and Mendelian randomization (MR) to investigate the intricate relationship between sarcopenia and OP.

Supramolecular PEG-DNA-Ferrocene Nanogels for Synergistically Amplified Chemodynamic Therapy via Cascade Reactions.

Chemodynamic therapy (CDT) has been limited by the tumor microenvironment, such as the low concentration of hydrogen peroxide (HO). The combination of therapeutic strategies that increase HO with CDT can synergistically enhance the therapeutic effect. Herein, a novel supramolecular PEG-DNA-ferrocene nanogel that can codeliver glucose oxidase (GOx) and the hypoxia-activable prodrug tirapazamine (TPZ) was developed to synergistically amplify CDT via cascade reactions.

Relationships between APOE, Type 2 Diabetes, and Cardiovascular Disease in Postmenopausal Women.

Background: The Apolipoprotein E (APOE) ε4 allele, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD) are well-established risk factors for dementia. Relationships between APOE and incidence of T2DM and CVD are not fully understood but may shed light on the mechanisms underlying dementia pathogenesis.

Methods: Postmenopausal women (N=6,795) from the Women's Health Initiative hormone therapy clinical trial with APOE genotyping and no prior diagnosis of T2DM or CVD were included.

A Prediction Nomogram of Severe Obstructive Sleep Apnea in Patients with Obesity Based on the Liver Stiffness and Abdominal Visceral Adipose Tissue Quantification.

Purpose: The diagnosis of severe OSA still relies on polysomnography, which causes a strong sense of restraint in patients with obesity. However, better prediction tools for severe OSA applicable to patients with obesity have not been developed.

Patients And Methods: Relevant clinical data of 1008 patients with OSA who underwent bariatric surgery in our hospital were collected retrospectively.

Expanding the Color Range of Photoresponsive Multicolor Luminescent System Through Host-Guest Interaction.

Photoresponsive multicolor luminescent systems offer interesting functions, which have led to applications in anticounterfeiting and biological imaging. However, expanding the color range of these materials remains a challenging task. Herein, a carbazole-modified dithienylethene derivative () that exhibits modulated fluorescence color changes through the photocyclization reaction and photolysis reaction is synthesized.

The learning curve of a dynamic navigation system used in endodontic apical surgery.

Background/purpose: Quantitative research was conducted on the learning process of a dynamic navigation system. This study provides guidance for the promotion and application of dynamic navigation technology in the endodontic apical surgery field.

Materials And Methods: Standardized models were designed and 3D printed to form the approach operation of endodontic apical surgery.

A novel aptasensor based endogenous enzyme-powered DNA walker for ATP imaging in specific living cells.

Highly sensitive and specific imaging of ATP in living cells remains a challenge. Here, a novel aptasensor based endogenous enzyme-powered DNA walker for imaging ATP was proposed. The strategy leverages the highly expressed APE1 in tumor cells as the driving force of the DNA walker, achieving high sensitivity and superior imaging contrast.

Dynamics of a susceptible-infected-recovered model on complex networks with interregional migration.

We present a susceptible-infected-recovered model based on a dynamic flow network that describes the epidemic process on complex metapopulation networks. This model views population regions as interconnected nodes and describes the evolution of each region using a system of differential equations. The next-generation matrix method is used to derive the global basic reproduction number for three cases: a general network with homogeneous infection rates in all regions, a fully connected network, and a star network with heterogeneous infection and recovery rates.

Urban flood-bearing vulnerability evaluation based on the moment estimate weighting and improved gray target model.

Increasingly severe flooding seriously threatens urban safety. A scientific urban flood-bearing vulnerability assessment model is significant to improve urban risk management capacity. The gray target model (GTM) has advantages in urban flood-bearing vulnerability assessment.

Dual electrochemical signal "signal-on-off" sensor based on CHA-Td-HCR and CRISPR-Cas12a for MUC1 detection.

Mucin 1 (MUC1) is frequently overexpressed in various cancers and is essential for early cancer detection. Current methods to detect MUC1 are expensive, time-consuming, and require skilled personnel. Therefore, developing a simple, sensitive, highly selective MUC1 detection sensor is necessary.

An interfacial host-guest inclusion complex regulated supramolecular nanocomposite hydrogel showing tunable mechanical strength, self-healing, strain sensitivity and NIR responsiveness.

The development of supramolecular nanocomposite hydrogels with good mechanical properties and multifunctional characteristics remains challenging. The reinforced role of interfacial weak interactions is important for the mechanical properties of nanocomposite hydrogels. Here, a dynamic host-guest inclusion complex from the host molecule CB[7] and guest units was employed to prepare FeO hybrid supramolecular nanocomposite hydrogels.

An assessment of compositional methods for the analysis of DNA methylation-based deconvolution estimates.

DNA methylation (DNAm)-based deconvolution estimates contain relative data, forming a composition, that standard methods (testing directly on cell proportions) are ill-suited to handle. In this study we examined the performance of an alternative method, analysis of compositions of microbiomes (ANCOM), for the analysis of DNAm-based deconvolution estimates. We performed two different simulation studies comparing ANCOM to a standard approach (two sample -test performed directly on cell proportions) and analyzed a real-world data from the Women's Health Initiative to evaluate the applicability of ANCOM to DNAm-based deconvolution estimates.

Investigating the Underlying Molecular Mechanisms of Yunke on Bone Metastases from Prostate Cancer.

Objective: To explore analgesic effect and bone repair mechanism of non-radioactive technetium-99 conjugated with methylene diphosphonate (Tc-MDP, brand name, Yunke) on bone metastases (BM).

Procedures: In vivo experiment, mouse BM models of prostate cancer RM-1 cell were constructed and divided into Control, Yunke, Tc+SnCl and MDP groups based on medicine composition. Tumor specimens were inspected for size, X-ray, microCT and histopathology.

A DNA walker based on hairpin-shaped DNA aligner and fueled by nicking endonuclease for sensitive and rapid miRNA analysis.

Background: DNA walker-based strategies have gained significant attention in nucleic acid analysis. However, they face challenges related to balancing design complexity, sequence dependence, and amplification efficiency. Furthermore, most existing DNA walkers rely on walking and lock probes, requiring optimization of various parameters like DNA probe sequence, walking-to-lock probe ratio, lock probe length, etc.

Identification of Differentially Expressed mRNAs and lncRNAs Contributes to Elucidation of Underlying Pathogenesis and Therapeutic Strategy of Recurrent Implantation Failure.

Recurrent implantation failure (RIF) is a complex and poorly understood clinical disorder characterized by failure to conceive after repeated embryo transfers. Endometrial receptivity (ER) is a prerequisite for implantation, and ER disorders are associated with RIF. However, little is known regarding the molecular mechanisms underlying ER in RIF.

Simultaneous multi-slice technique for reducing acquisition times in diffusion tensor imaging of the knee: a feasibility study.

Objectives: To explore the feasibility of simultaneous multi-slice (SMS) technique for reducing acquisition times in readout-segmented echo planar imaging (RESOLVE) for diffusion tensor imaging (DTI) of the knee.

Materials And Methods: A total of 30 healthy volunteers and 23 patients with knee acute injury (12 cases with anterior ligament (ACL) tears and 16 cases with patellar cartilage (PC) injury) were enrolled in this prospective study. Three DTI protocols were used: conventional RESOLVE-DTI with 12 directions (protocol 1), SMS-RESOLVE-DTI with 12 directions (protocol 2) and 20 directions (protocol 3).

Development of a national database for dietary glycemic index and load for nutritional epidemiologic studies in the United States.

Background: The quality of carbohydrate intake, as measured by the glycemic index (GI), has not been evaluated nationally over the past 2 decades in the United States.

Objectives: We aimed to develop a comprehensive and nationally representative dietary GI and glycemic load (GL) database from 1999 to 2018 National Health and Nutrition Examination Survey (NHANES) and to examine GI and GL time trends and subpopulation differences.

Methods: We used an artificial intelligence (AI)-enabled model to match GI values from 2 GI databases to food codes from United States Department of Agriculture, which were manually validated.