Inflammatory cytokines and oral cancer risk: an integrated study combining two-sample Mendelian randomization with experimental validation.

Objective: This study aimed to investigate the causal relationship between inflammatory cytokines and oral cavity cancer risk using Mendelian randomization analysis and experimental validation.

Methods: Two-sample Mendelian randomization was conducted using summary-level genome-wide association study data on 41 inflammatory cytokines and oral cavity cancer risk in Europeans. Single nucleotide polymorphisms associated with cytokines (p < 5 × 10-6) and oral cancer were selected as instrumental variables, excluding those in linkage disequilibrium.

Simple synthesis and excellent performance of the cow dung-based biodegradable liquid mulch for sustainable agriculture.

The environmental pollution caused by the extensive use of plastic films in farmland and the discharge of large amounts of manure from animal husbandry has seriously affected the sustainable development of global agriculture and environment. In this study, using cow manure as raw material, a cow dung-based biodegradable liquid mulch (CD-BA) was synthesized through grafting polymerization and as an eco-friendly alternative to the traditional agricultural plastic film. By studying the effects of the proportion of cow manure raw materials and additives on the performance of liquid plastic film, the optimal CD-BA was synthesized with 48.

Toe-out landing reduces anterior talofibular ligament strain while maintains calcaneofibular ligament strain in people with chronic ankle instability.

Background: The anterior talofibular ligament (ATFL) and the calcaneofibular ligament (CFL) are vulnerable to be torn or ruptured during lateral ankle sprain (LAS), especially in people with chronic ankle instability (CAI). This study aims to determine whether landing with a larger toe-out angle would influence ATFL and CFL strains in people with CAI, aiming to contribute to the development of effective landing strategies to reduce LAS risk.

Methods: Thirty participants with CAI (22 males and 8 females, age: 21.

Clinical application of bile acid profile combined with lipid indices in metabolic dysfunction-associated steatotic liver disease.

Objective: This study aims to investigate the diagnostic potential of bile acid profiles combined with lipid parameters in metabolic dysfunction-associated steatotic liver disease (MASLD).

Method: This study employed LC-MS technology to analyze the serum bile acid profiles of 186 male patients with MASLD and 80 male non-MASLD patients. According to whether the serum samples exhibit dyslipidemia, the subjects were divided into four groups.

Ligand Strategies for Regulating Atomically Precise CeO Nanoparticles: From Structure to Property.

The increasing interest in studying the structure-property relationships of ceria dioxide (CeO) relies on the fact that many factors are key to determining the performance of CeO materials. Despite the great advances achieved, it remains a formidable challenge to regulate CeO nanoparticles at the molecular level and gain in-depth insight into their structure-property relationships. What is reported here is a ligand strategy for regulating CeO nanoparticles, in terms of not only shape, structure, surface composition, but also property.

Risk factors of stroke-related sarcopenia: a systematic review and meta-analysis.

Background: The presence of sarcopenia at the time of stroke may deteriorate the rehabilitation and functional outcomes. There is no consensus on the factors associated with stroke-related sarcopenia because previous studies produced inconsistent and disputed results. Therefore, we screened the possible risk factors by meta-analysis.

Shaping oral and intestinal microbiota and the immune system during the first 1,000 days of life.

The first 1, 000 days of life, from the fetal stage of a woman's pregnancy to 2 years of age after the baby is born, is a critical period for microbial colonization of the body and development of the immune system. The immune system and microbiota exhibit great plasticity at this stage and play a crucial role in subsequent development and future health. Two-way communication and interaction between immune system and microbiota is helpful to maintain human microecological balance and immune homeostasis.

Polydopamine-coated cerium oxide core-shell nanoparticles for efficient and non-damaging chemical-mechanical polishing.

Chemical mechanical polishing (CMP) represents one of the most important steps in the manufacturing of integrated circuits, and high surface quality is always required for the CMP processes of shallow trench isolation (STI) structures. Herein, a new series of polydopamine (PDA)-coated cerium oxide core-shell nanoparticles has been developed as efficient and non-damaging abrasives for CMP of SiO on the surface of silicon wafers. The composite abrasives with the structure of SiO@CeO@PDA have been fabricated in a simple manner and thoroughly characterized using scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy.

Fiber transmission model with parameterized inputs based on generative pre-trained physics-informed neural networks.

In this manuscript, a principle-driven fiber transmission model for short-distance transmission with parameterized inputs is put forward. By taking into account the previously proposed principle-driven fiber model as the basic solution solver, the reduced basis expansion method and transforming the parameterized inputs into parameterized coefficients of the Nonlinear Schrödinger Equations, universal solutions with respect to inputs corresponding to different bit rates can all be obtained without the need of re-training the whole model. Once adopted, this model can have prominent advantages in both computation efficiency and physical background.

Atomically Precise Cu Nanoclusters with Thermally Activated Delayed Fluorescence Properties.

Ligand-stabilized metal nanoclusters with atomic precision are considered to be promising materials in the field of light-emitting and harvesting. Among these, nanoclusters with thermally activated delayed fluorescence (TADF) properties are highly sought after. While several gold and silver nanoclusters with TADF properties have been reported in recent years, research on copper counterparts has significantly lagged behind.

Computational evaluation of interactive dynamics for a full transcatheter aortic valve device in a patient-specific aortic root.

Transcatheter aortic valve implantation (TAVI) has become a key treatment for severe aortic stenosis, especially for patients unsuitable for surgery. Since its introduction in 2002, TAVI has advanced significantly due to improvements in imaging, operator skills, and device engineering. Despite these innovations, challenges in device sizing and positioning remain, complicating outcome predictions.

Corrigendum: Network-based prediction of anti-cancer drug combinations.

[This corrects the article DOI: 10.3389/fphar.2024.

Class III peroxidase: An essential enzyme for enhancing plant physiological and developmental process by maintaining the ROS level: A review.

Since plants are sessile organisms, they are inevitably exposed to various environmental stresses, and the accumulation of reactive oxygen species (ROS) could affect the growth and development of plants. ROS play either positive or negative roles in various plant life activities as a two-edge sword. Class III peroxidase (CIII PRX) is a highly conserved antioxidant enzyme family specifically identified in plants, which is involved in maintaining ROS homeostasis in the cell and plays multiple functions in plant growth metabolism and stress response.

Electric-Field-Driven Redistribution of Carriers on Catalyst Particles to Improve Photocatalytic Performance.

The photocatalytic performance is primarily determined by carrier separation efficiency. Applying electric fields to enhance carrier separation efficiency and thereby boost catalytic performance has emerged as a promising approach. However, the carrier behavior on catalyst particles under electric fields was still hardly acknowledged.

Triphenylamine-Functionalized Metal Nanoclusters for Efficient and Stable Perovskite Solar Cells.

Reported herein is a ligand engineering strategy to develop photoelectric active metal nanoclusters (NCs) with atomic precision. Triphenylamine (TPA), a typical organic molecule in the photoelectric field, is introduced for the first time to prepare atomically precise metal NCs that prove effective in the fabrication of perovskite solar cells (PSCs). The scalable synthetic prototype, unique electronic strucuture, and atomically precise structure of the cluster ([(AgCu)(PPh)(TPA-C≡C)]) are illustrated in this work.

Deciphering the oncogenic potential of ADAM9 in hepatocellular carcinoma through bioinformatics and experimental approaches.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. This study investigates the role and mechanisms of ADAM9 as a biomarker and potential therapeutic target in HCC. Utilizing RNA-sequencing data and clinicopathological characteristics from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, we conducted survival and meta-analyses, functional enrichment, and immune infiltration studies.

Analysis of factors associated with tooth loss in older adults from 1995 to 2015: a population-based cross-sectional survey in Guangdong, China.

Objectives: The aim of this study was to detect trends and related factors in the functional dentition (FD) in 65- to 74-year-olds in Guangdong, China, while also assessing trends in education and income inequality factors.

Materials And Methods: Three large-scale cross-sectional National Oral Health Surveys (NOHS), specifically NOHS II in 1995, NOHS III in 2005, and NOHS IV in 2015, were included. Post hoc stratification was weighted for 1038 participants aged 65 to 74years.

An mRNA methylase and demethylase regulate sorghum salt tolerance by mediating N6-methyladenosine modification.

N 6-methyladenosine (m6A) modification is a crucial and widespread molecular mechanism governing plant development and stress tolerance. The specific impact of m6A regulation on plants with inherently high salt tolerance remains unclear. Existing research primarily focuses on the overexpression or knockout of individual writer or eraser components to alter m6A levels.

N-Heterocyclic carbene-stabilized gold-copper nanoclusters: synthesis, bonding and mechanochromism.

N-Heterocyclic carbene (NHC) ligands have emerged as highly effective surface ligands for the protection and functionalization of metal nanoclusters (NCs). However, research on NHC-stabilized metal NCs, including their synthesis, structure, properties, and applications, is still in its early stages. In this study, we present the first gold-copper alloy cluster protected by both NHC and alkyne ligands, denoted as AuCu(NHC)(PA) (abbreviated as AuCu, where NHC is a bidentate N-heterocyclic carbene ligand with isopropyl as the N-substituent, and PA is a phenylethynyl group).

Anchoring Frustrated Lewis Pair Active Sites on Copper Nanoclusters for Regioselective Hydrogenation.

In recent years, the concept of Frustrated Lewis Pairs (FLPs), which consist of a combination of Lewis acid (LA) and Lewis base (LB) active sites arranged in a suitable geometric configuration, has been widely utilized in homogeneous catalytic reactions. This concept has also been extended to solid supports such as zeolites, metal oxide surfaces, and metal/covalent organic frameworks, resulting in a diverse range of heterogeneous FLP catalysts that have demonstrated notable efficiency and recyclability in activating small molecules. This study presents the successful immobilization of FLP active sites onto the surface of ligand-stabilized copper nanoclusters with atomic precision, leading to the development of copper nanocluster FLP catalysts characterized by high reactivity, stability, and selectivity.

Association between sleep disorder and depression in stroke in the National Health and Nutrition Examination Surveys (NHANES) 2005 to 2014.

Background: To investigate the association between sleep disorder and depression in stroke population using data from the National Health and Nutrition Examination Surveys (NHANES) conducted between 2005 and 2014.

Methods: Participants included stroke population who reported on sleep disorder and completed the Patient Health Questionnaire-9 (PHQ-9) to assess depressive symptom. Sleep disorder was self-reported and categorized dichotomously.

Causal inference of the effect of plasma proteins on the incidence of oral cancer: two-sample Mendelian randomization.

Objective: This study is aimed to investigate the causal relationship between plasma proteins and oral cancer risk using two-sample MR (Mendelian randomization).

Methods: Summary-level GWAS (genome-wide association study) data on plasma protein levels (4,907 proteins) and oral cancer (6,034 cases, 6,585 controls) of European ancestry were utilized. SNPs (single nucleotide polymorphisms) associated with proteins at genome-wide significance were selected as instrumental variables.