Momordin Ic ameliorates psoriasis skin damage in mice via the IL-23/IL-17 axis.

Psoriasis, a chronic and easily recurring inflammatory skin disease, causes a great economic burden to the patient's family because the etiology and mechanism are still unclear and the treatment cycle is long. In this study, the function and related mechanisms of Momordin Ic in psoriasis were investigated. The IMQ-induced mouse psoriasis model was constructed.

Functional hemostatic hydrogels: design based on procoagulant principles.

Uncontrolled hemorrhage results in various complications and is currently the leading cause of death in the general population. Traditional hemostatic methods have drawbacks that may lead to ineffective hemostasis and even the risk of secondary injury. Therefore, there is an urgent need for more effective hemostatic techniques.

Recent advances in biomimetic hemostatic materials.

Although the past decade has witnessed unprecedented medical advances, achieving rapid and effective hemostasis remains challenging. Uncontrolled bleeding and wound infections continue to plague healthcare providers, increasing the risk of death. Various types of hemostatic materials are nowadays used during clinical practice but have many limitations, including poor biocompatibility, toxicity and biodegradability.

Functional and clinical characteristics of focal adhesion kinases in cancer progression.

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in response to stress. Increasing evidence has shown that at the pathological level, FAK is highly expressed in multiple tumors in several systems (including lung, liver, gastric, and colorectal cancers) and correlates with tumor aggressiveness and patient prognosis.

Case Report: Clostridial Gas Gangrene of Pelvic Wall After Laparoscopic Rectal Cancer Surgery Induced Fatal Sepsis.

Clostridial gas gangrene is an unusual but fast-spreading necrotic infection of soft tissue relevant to high mortality rates. We report a case of postoperative gas gangrene of the pelvic wall, scrotum, and perineal site, with very acute onset and rapid progression of symptoms after laparoscopic radical resection for rectal cancer. Although potentially treatable with appropriate antibiotic cover and urgent thorough surgical debridement, this case still developed irreversibly into fulminant and fatal sepsis.