Association between serum levels of insulin-like growth factor-binding proteins at admission and outcomes at 3 months after acute ischemic stroke.

Background: Insulin-like growth factor-binding proteins (IGFBPs) contribute to central nervous system development and may influence recovery after stroke. This study aimed to determine whether serum IGFBPs levels in acute ischemic stroke (AIS) patients are associated with 3-month outcomes.

Materials And Methods: We retrospectively reviewed data from AIS patients admitted within 24 h after stroke onset, and who had been prospectively enrolled in the Chengdu Stroke Registry.

Efficacy and safety of corticosteroids for stroke and traumatic brain injury: a systematic review and meta-analysis.

Background: Corticosteroids are frequently used in practice to treat patients with neurological disorders. However, its effect for stroke and traumatic brain injury (TBI) remains controversial. This study aimed to systematically review and evaluate efficacy and safety of corticosteroids for the treatment of stroke and TBI.

Neuroimaging predictors of malignant brain oedema after thrombectomy in ischemic stroke: a systematic review and meta-analysis.

Background: We systematically reviewed neuroimaging predictors for malignant brain oedema (MBE) after thrombectomy in patients with ischemic stroke.

Methods: We searched MEDLINE and EMBASE in November 2023 for studies of patients with ischemic stroke. We included studies investigating neuroimaging predictors or prediction models for MBE after thrombectomy.

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke.

Stroke is a leading cause of death and disability worldwide. Most cases of stroke are ischemic and result from the occlusion of the middle cerebral artery (MCA). Current pharmacological approaches for the treatment of ischemic stroke are limited; therefore, novel therapies providing effective neuroprotection against ischemic injury following stroke are urgently needed.

Etiologies and Risk Factors by Sex and Age in Young Adult Patients with Ischemic Stroke.

Aim: The aim of this study was to explore etiologies and risk factors by age and sex in young adult patients with ischemic stroke.

Methods: We recruited patients with ischemic stroke aged between 18 and 49 years. We assessed pathological etiologies by the Trial of Org 10,172 in Acute Stroke Treatment (TOAST) classification and risk factors by the International Pediatric Stroke Study (IPSS) classification.

Development of L-Met functionalized cellulose nanofiber for an efficient removal of Pb from aqueous solution: Characterization, adsorption behavior, DFT calculations and physiochemical mechanism.

Lead-containing wastewater has been a significant challenge in the field of wastewater treatment. Cellulose surface has a large number of active sites, which is conducive to load modification. And amino acids have rich functional groups, which is a good choice for cellulose modification.

World Stroke Organization (WSO): Global intracerebral hemorrhage factsheet 2025.

Background: Intracerebral hemorrhage (ICH) is stroke caused by non-traumatic bleeding into the brain.

Aim: This factsheet provides summary statistics for ICH from the 2021 Global of Burden of Diseases Study.

Methods: Data were downloaded from the GBD results platform using "intracerebral hemorrhage" as a Level 4 cause of death or injury, extracting key metrics (number, percent, rate) for measures (incidence, disabilty adjusted life years [DALYs], deaths) described in this factsheet.

Effects of wheat cultivar, bran concentration and endoxylanase on the thermomechanical, viscoelastic and microstructural properties of whole wheat flour dough.

Globally, it is challenging to promote the market of whole wheat product due to its undesirable product quality issues. To overcome this remarkable challenge, this research was to work on the constructive strategies for mitigating the negative impact of wheat bran. As such, the objective of this research was to investigate how the wheat cultivar, bran concentration and endoxylanase affected dough thermomechanical properties, viscoelasticity and microstructure by a combined use of mixolab, rheometry, scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM).

Pharmacological inhibition of RUNX1 reduces infarct size after acute myocardial infarction in rats and underlying mechanism revealed by proteomics implicates repressed cathepsin levels.

Myocardial infarction (MI) results in prolonged ischemia and the subsequent cell death leads to heart failure which is linked to increased deaths or hospitalizations. New therapeutic targets are urgently needed to prevent cell death and reduce infarct size among patients with MI. Runt-related transcription factor-1 (RUNX1) is a master-regulator transcription factor intensively studied in the hematopoietic field.

Intravenous Alteplase Versus Best Medical Therapy for Patients With Minor Stroke: A Systematic Review and Meta-Analysis.

Background: The efficacy of thrombolysis (IVT) in minor stroke (National Institutes of Health Stroke Scale score, 0-5) remains inconclusive. The aim of this study is to compare the effectiveness and safety of IVT with best medical therapy (BMT) by means of a systematic review and meta-analysis of randomized controlled trials and observational studies.

Methods: We searched the PubMed, Embase, Cochrane Library, and Web of Science databases to obtain articles related to IVT in minor stroke from inception until August 10, 2023.

Nano‑selenium functionalized chitosan gel beads for Hg(II) removal from apple juice.

The presence of potentially toxic elements and compounds poses threats to the quality and safety of fruit juices. Among these, Hg(II) is considered as one of the most poisonous heavy metals to human health. Traditional chitosan-based and selenide-based adsorbents face challenges such as poor adsorption capacity and inconvenient separation in juice applications.

Definition, prediction, prevention and management of patients with severe ischemic stroke and large infarction.

Severe ischemic stroke carries a high rate of disability and death. The severity of stroke is often assessed by the degree of neurological deficits or the extent of brain infarct, defined as severe stroke and large infarction, respectively. Critically severe stroke is a life-threatening condition that requires neurocritical care or neurosurgical intervention, which includes stroke with malignant brain edema, a leading cause of death during the acute phase, and stroke with severe complications of other vital systems.

Systematic review: Pharmacological interventions for the treatment of post-stroke fatigue.

Background: Post-stroke fatigue (PSF) affects around 50% of stroke survivors. Previous systematic reviews of randomized controlled trials found insufficient evidence to guide practice, but most excluded Chinese studies. Furthermore, their searches are now out-of-date.

Prognostic value of day-of-event serum calcium and magnesium for predicting 1-year prognosis after intracerebral hemorrhage.

Aim: To investigate whether serum calcium and magnesium on the day of symptom onset contribute to prognosis at 1 year after intracerebral hemorrhage (ICH).

Methods: We prospectively enrolled patients admitted < 24 h after symptom onset of primary ICH to West China Hospital between January 2012 and October 2014. Blood samples were collected at admission to determine the concentration of serum calcium and magnesium.

Adsorptive performance and mechanism exploration of l-lysine functionalized celluloses for enhanced removal of Pb(II) from aqueous medium.

In this study, two novel biosorbents of l-lysine grafted cellulose (L-PCM, L-TCF) were prepared for Pb(II) removal from aqueous solutions. Various adsorption parameters were surveyed, such as adsorbent dosages, initial concentration of Pb(II), temperature and pH, using adsorption techniques. At normal temperature, less adsorbent can achieve better adsorption capacity (89.

Predicting the emergence of malignant brain oedema in acute ischaemic stroke: a prospective multicentre study with development and validation of predictive modelling.

Background: We aimed to develop and validate a prognostic model for predicting malignant brain oedema in patients with acute ischaemic stroke in a real-world setting of practice.

Methods: A prospective multicentre study enrolled adult patients with acute ischaemic stroke with brain CT < 24 h of onset of symptoms admitted to nine tertiary-level hospitals in China between September 2017 and December 2019. Malignant brain oedema was defined as any patient who had decompressive craniectomy, discharge in coma, or in-hospital death attributed to symptomatic brain swelling.

Preparation and modification of nanocellulose and its application to heavy metal adsorption: A review.

Heavy metals are a notable pollutant in aquatic ecosystems that results in many deadly diseases of the human body after enrichment through the food chain. As an environmentally friendly renewable resource, nanocellulose can be competitive with other materials at removing heavy metal ions due to its large specific surface area, high mechanical strength, biocompatibility and low cost. In this review, the research status of modified nanocellulose for heavy metal adsorbents is primarily reviewed.

A systematic review and synthesis of global stroke guidelines on behalf of the World Stroke Organization.

Background: There are multiple stroke guidelines globally. To synthesize these and summarize what existing stroke guidelines recommend about the management of people with stroke, the World Stroke Organization (WSO) Guideline committee, under the auspices of the WSO, reviewed available guidelines.

Aims: To systematically review the literature to identify stroke guidelines (excluding primary stroke prevention and subarachnoid hemorrhage) since 1 January 2011, evaluate quality (The international Appraisal of Guidelines, Research and Evaluation (AGREE II)), tabulate strong recommendations, and judge applicability according to stroke care available (minimal, essential, advanced).

Adenomyosis-Associated Ischemic Stroke: Pathophysiology, Detection and Management.

Female-specific risk factors for stroke have gradually received attention. The relationship between ischemic stroke and adenomyosis, a benign uterine disorder commonly present in parous women, is underrecognized. We aimed to provide an overview of the epidemiology, pathophysiological mechanisms, clinical characteristics, diagnostic considerations, and potential therapeutic strategies of adenomyosis-associated ischemic stroke.

Increasing burden of stroke in China: A systematic review and meta-analysis of prevalence, incidence, mortality, and case fatality.

Background: The epidemiology of stroke is evolving in China as the population undergoes demographic, lifestyle, and economic transitions. An updated review is pertinent to providing feedback on current, and in planning future, prevention and management strategies.

Aims: To identify high-quality epidemiological studies for quantifying the prevalence, incidence, mortality, and case fatality for stroke in China.