Publications by authors named "Simeon Tsohataridis"

Introduction: The exposome concept includes nutrition as it significantly influences human health, impacting the onset and progression of diseases. Gluten-containing wheat products are an essential source of energy for the world's population. However, a rising number of non-celiac healthy individuals tend to reduce or completely avoid gluten-containing cereals for health reasons.

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Sepsis causes high mortality in the setting of septic shock. LEADER and other trials revealed cardioprotective and anti-inflammatory properties of glucagon-like peptide-1 (GLP-1) analogs like liraglutide (Lira). We previously demonstrated improved survival in lipopolysaccharide (LPS)-induced endotoxemia by inhibition of GLP-1 degradation.

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During the perinatal period, the brain is highly vulnerable to hypoxia and inflammation, which often cause white matter injury and long-term neuronal dysfunction such as motor and cognitive deficits or epileptic seizures. We studied the effects of moderate hypoxia (HYPO), mild systemic inflammation (INFL), or the combination of both (HYPO+INFL) in mouse somatosensory cortex induced during the first postnatal week on network activity and compared it to activity in SHAM control animals. By performing in vitro electrophysiological recordings with multi-electrode arrays from slices prepared directly after injury (P8-10), one week after injury (P13-16), or in young adults (P28-30), we investigated how the neocortical network developed following these insults.

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Neurovascular coupling (NVC) in the adult central nervous system (CNS) is a mechanism that provides regions of the brain with more oxygen and glucose upon increased levels of neural activation. Hemodynamic changes that go along with neural activation evoke a blood oxygen level-dependent (BOLD) signal in functional magnetic resonance imaging (fMRI) that can be used to study brain activity non-invasively. A correct correlation of the BOLD signal to neural activity is pivotal to understand this signal in neuronal development, health and disease.

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Synopsis of recent research by authors named "Simeon Tsohataridis"

  • - Simeon Tsohataridis's recent research focuses on the intersection of diet, inflammation, and vascular health, with specific attention to the impact of short-term dietary changes and pharmacological interventions on cardiovascular biomarkers and quality of life.
  • - His work highlights the effects of glucagon-like peptide-1 (GLP-1) analogs, particularly liraglutide, in improving vascular function during conditions of polymicrobial sepsis, emphasizing its cardioprotective and anti-inflammatory properties.
  • - Tsohataridis has also investigated neurovascular coupling and its developmental changes in the immature rodent brain, examining how systemic inflammation and hypoxia can alter neuronal excitability, which has implications for understanding neurodevelopmental disorders.