Involvement of functional senescence in efavirenz-induced toxicity in fruit fly.

Background: We aimed in this article to assess the likeliness of efavirenz to induce functional senescence in (fruit fly).

Methods: Ten different concentrations of EFV were mixed with fly food and fed to 3-day-old flies orally for a 7 day LC calculation. Drug concentrations from LC were selected for a 28 day survival to determine the duration of treatment for behavioral and biochemical assays.

A systematic analysis of anti-diabetic medicinal plants from cells to clinical trials.

Background: Diabetes is one of the fastest-growing health emergencies of the 21 century, placing a severe economic burden on many countries. Current management approaches have improved diabetic care, but several limitations still exist, such as decreased efficacy, adverse effects, and the high cost of treatment, particularly for developing nations. There is, therefore, a need for more cost-effective therapies for diabetes management.

Benzo[a]pyrene and Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide induced locomotor and reproductive senescence and altered biochemical parameters of oxidative damage in Canton-S .

Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon (PAH) commonly found in cigarette smoke, automobile exhaust fumes, grilled meat, and smoked food among others. Exposure to B[a]P is associated with a range of toxic effects including developmental, neurological, oxidative, inflammatory, mutagenic, carcinogenic and mortal. Efficient and more affordable experimental models like could provide more insight into the mechanism of PAH toxicity and help develop new strategies for prevention, diagnosis and treatment of PAH-related conditions.

Medicine Vendors: Self-medication Practices and Medicine Knowledge.

Background: Medicine vendors fill the gap created by inadequate skilled professionals required for medicine procurement, storage, and distribution in developing countries.

Aim: To evaluate self-medication practice and medicine knowledge among medicine vendors and to determine if a relationship exists between both.

Materials And Methods: A descriptive, cross-sectional study was conducted, using a pretested questionnaire on 236 medicine vendors in Jos, Nigeria, sampled through a two-stage stratified design.

Analysis of some biochemical and haematological parameters for Mucuna pruriens (DC) seed powder in male rats.

The biochemical and haematological effects of the seed powder of Mucuna pruriens in male rats were evaluated to establish some biological properties of this potential biopesticide currently undergoing investigation. The result showed that Mucuna pruriens seed extract produced a significant (p<0.05) increase in white blood cell (WBC) count, as well as in bilirubin concentrations, alkaline phosphatase (ALP), protein and creatinine levels measured.