Publications by authors named "Simeng An"
The human brain is a dynamic system that shows frequency-specific features. Neuroimaging studies have shown that both healthy individuals and those with chronic pain disorders experience pain influenced by various processes that fluctuate over time. Primary dysmenorrhea (PDM) is a chronic visceral pain that disrupts the coordinated activity of brain's functional network.
View Article and Find Full Text PDFBackground: The brain in resting state has complex dynamic properties and shows frequency dependent characteristics. The frequency-dependent whole-brain dynamic changes of resting state across the scans have been ignored in Alzheimer's disease (AD).
Objective: Coactivation pattern (CAP) analysis can identify different brain states.
Article Synopsis
- Research identifies three key brain networks that are affected during resting states in Alzheimer's patients: the default mode network (DMN), salient network (SN), and central executive network (CEN).
- Using an innovative method called energy landscape, the study examines how these networks function differently in Alzheimer's patients compared to healthy individuals.
- Findings reveal that Alzheimer's patients exhibit unstable brain dynamics with heightened flexibility in state transitions, which correlates with clinical symptoms, thus shedding light on the underlying mechanisms of brain activity in the condition.