Publications by authors named "Simantini Sakhardande"
Article Synopsis
- Subjects with systemic lupus erythematosus (SLE) have a higher risk of cardiovascular disease (CVD) that isn't fully captured by traditional risk assessments, prompting this study to explore nuclear MR (NMR) spectroscopy for evaluating lipoprotein levels and GlycA.
- The study used coronary CT angiography to assess plaque burden in SLE patients and healthy controls, finding significant differences in lipoprotein particle counts and sizes between the two groups.
- Results indicate that SLE patients exhibit a harmful lipoprotein profile, with decreased high-density lipoprotein (HDL) and increased very low-density lipoprotein (VLDL), suggesting that NMR measurements of GlycA and lipoproteins could better
Background: Systemic lupus erythematosus (SLE) is associated with enhanced risk of atherosclerotic cardiovascular disease not explained by Framingham risk score (FRS). Immune dysregulation associated to a distinct subset of lupus proinflammatory neutrophils (low density granulocytes; LDGs) may play key roles in conferring enhanced CV risk. This study assessed if lupus LDGs are associated with in vivo vascular dysfunction and inflammation and coronary plaque.
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