Publications by authors named "Sima Saki"
Article Synopsis
- - SALL4 is a transcription factor linked to embryonic pluripotency and is researched as a marker for diagnosing testicular germ cell tumors (TGCTs), particularly focusing on its full-length variant, SALL4-A.
- - A study examining 124 TGCTs found that SALL4-A was significantly more expressed in tumors than in normal tissues, with seminomas and yolk sac tumors showing the highest levels.
- - Findings suggest that higher SALL4-A expression in seminomas may predict poorer outcomes and is correlated with tumor progression and recurrence in different types of TGCTs.
Introduction: Melanoma-associated antigen A2 (MAGE-A2) is a member of the cancer-testis antigen family differentially overexpressed in a variety of malignancies and is associated with tumor development. However, clinical significance and prognostic value of MAGE-A2 in different histological subtypes of testicular germ cell tumors (TGCTs) have not been explored.
Materials And Methods: Here, we aimed to investigate the clinical significance and prognostic impact of MAGE-A2 expression in TGCTs compared to benign tumors as well as adjacent normal tissues and then between seminomas and non-seminomas groups using immunohistochemistry on tissue microarrays.