The potential for continuous infusion of cimetidine to affect the clearance of aminophylline was assessed in 18 critically ill patients treated for bronchospasm. This was a pharmacokinetic drug-drug interaction study in which the subjects were administered aminophylline as a continuous infusion at low doses (mean 10.8 mg/hr).
View Article and Find Full Text PDFJ Chromatogr B Analyt Technol Biomed Life Sci
April 2003
Generalized least squares regression with variance function estimation was used to derive the calibration function for measurement of methotrexate plasma concentration and its results were compared with weighted least squares regression by usual weight factors and also with that of ordinary least squares method. In the calibration curve range of 0.05 to 100 microM, both heteroscedasticity and non-linearity were present therefore ordinary least squares linear regression methods could result in large errors in the calculation of methotrexate concentration.
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