Cisplatin Alters Sodium Excretion and Renal Clearance in Rats: Gender and Drug Dose Related.

Background: Nephrotoxicity is one of the side effects of cisplatin (CP) therapy which is gender related. CP disturbs renal function through glomerular filtration rate and electrolytes transport disturbances. This study was designed to compare some markers related to renal function in two protocols of CP treatment in rats.

Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender Differences.

Cisplatin (CDDP) has been widely used as a chemotherapeutic agent for solid tumors. The most common side effect of CDDP is nephrotoxicity, and many efforts have been made in the laboratory and the clinic to employ candidate adjuvants to CDDP to minimize this adverse influence. Many synthetic and herbal antioxidants as well as trace elements have been investigated for this purpose in recent years and a variety of positive and negative results have been yielded.

Effect of enalapril in cisplatin-induced nephrotoxicity in rats; gender-related difference.

Background: The function of renin angiotensin system (RAS) is gender-related, and this system affects cisplatin (CP)-induced nephrotoxicity. In this study, we compared the effect of enalapril as an angiotensin-converting enzyme (ACE) inhibitor on CP-induced nephrotoxicity between male and female rats.

Materials And Methods: Sixty-two adult male and female Wistar rats were divided into eight groups.

Pomegranate Flower Extract does not Prevent Cisplatin-Induced Nephrotoxicity in Female Rats.

Background: Nephrotoxicity is the major side-effect of cisplatin (CDDP), and it is reported to be gender-related. We evaluated the effects of pomegranate flower extract (PFE) as an antioxidant on CDDP-induced nephrotoxicity in female rats.

Methods: Twenty-three adult female rats in four groups treated as following.

Vitamin e is a nephroprotectant agent in male but not in female in a model of Cisplatin-induced nephrotoxicity.

Background. The role of gender for nephroprotectant agent such as vitamin E in cisplatin- (CP-) induced nephrotoxicity has not been documented yet. Methods.