Publications by authors named "Sima Hirani"
Article Synopsis
- Human peripheral monocytes are divided into three subsets based on CD14 and CD16 expression levels, which relate to their roles in autoimmunity.
- This study finds that patients with autoimmune uveitis have increased intermediate CD14(++)CD16(+) monocytes, particularly influenced by glucocorticoid therapy.
- The research highlights that these intermediate monocytes suppress naive and memory CD4(+) T cell activity, while also promoting regulatory T cell responses, indicating their unique role in the immune response.
In this study we investigated the role of blood CD1c(+) myeloid dendritic cells 1 (mDC1), a key mDC subtype, in patients with autoimmune uveitis. We observed a significant increase of blood CD1c(+) mDC1 in uveitis patients. The increased CD1c(+) mDC1 exhibited high HLADR expression and less antigen uptake.
View Article and Find Full Text PDFGlucocorticoids remain the cornerstone of treatment for inflammatory conditions, but their utility is limited by a plethora of side effects. One of the key goals of immunotherapy across medical disciplines is to minimize patients' glucocorticoid use. Increasing evidence suggests that variations in the adaptive immune response play a critical role in defining the dose of glucocorticoids required to control an individual's disease, and Th17 cells are strong candidate drivers for nonresponsiveness [also called steroid resistance (SR)].
View Article and Find Full Text PDFDendritic cells (DCs) are a heterogeneous population. Murine DCs consist of conventional DCs (cDCs) and plasmacytoid DCs (pDCs). In humans, the analogous populations are myeloid DCs (mDCs) and pDCs.
View Article and Find Full Text PDFBackground: Sarcoidosis is a chronic inflammatory disease with a systemic granulomatous disorder affecting multiple organs including the eye. Both CD4+ T cell and macrophage have been linked to the pathogenesis of the disease.
Methods: The expression of IL-17RC was measured using FACS,immunohistochemistry and real-time PCR.