A novel self-supportive thin film based on graphene oxide reinforced chitosan nano-biocomposite for thin film microextraction of fluoxetine in biological and environmental samples.

In this research, for the first time, graphene oxide doped chitosan (GO/CS) nano-biocomposite (NBC) is designed and prepared as a novel self-supportive thin layer for thin film microextraction (TFME) of fluoxetine (FLX) followed by determination applying HPLC-UV-Vis. The properties of the prepared self-supportive thin film were characterized applying ATR-FTIR, FESEM, and XRD techniques. The extraction capability of GO/CS NBC toward FLX has been evaluated, and the obtained results revealed that incorporation of GO into CS has led to higher extraction efficiency in comparison to the CS thin film.