Publications by authors named "Silvio Halpern"
Human Fallopian Tube - Derived Mesenchymal Stem Cells Inhibit Experimental Autoimmune Encephalomyelitis by Suppressing Th1/Th17 Activation and Migration to Central Nervous System.
Stem Cell Rev Rep
February 2022
Article Synopsis
- Mesenchymal stem cells (MSCs) are undifferentiated cells found in adult tissues that show promise for treating various diseases due to their ability to renew and differentiate into different cell types while modulating immune responses.
- This study focused on human tubal mesenchymal stem cells (htMSCs) and their effects in an experimental autoimmune encephalomyelitis (EAE) model, revealing their ability to suppress the activation of dendritic cells and promote anti-inflammatory cytokine release.
- Results indicated that htMSCs lead to milder disease symptoms, with reduced immune cell infiltration and increased levels of protective factors, suggesting their potential as a therapy for inflammatory and neurodegenerative conditions.
Murine endometrial-derived mesenchymal stem cells suppress experimental autoimmune encephalomyelitis depending on indoleamine-2,3-dioxygenase expression.
Clin Sci (Lond)
May 2021
Cellular therapy with mesenchymal stem cells (MSCs) is a huge challenge for scientists, as little translational relevance has been achieved. However, many studies using MSCs have proved their suppressive and regenerative capacity. Thus, there is still a need for a better understanding of MSCs biology and the establishment of newer protocols, or to test unexplored tissue sources.
View Article and Find Full Text PDFCorrection: Human Tubal-Derived Mesenchymal Stromal Cells Associated with Low Level Laser Therapy Significantly Reduces Cigarette Smoke-Induced COPD in C57BL/6 mice.
PLoS One
December 2015
Human Tubal-Derived Mesenchymal Stromal Cells Associated with Low Level Laser Therapy Significantly Reduces Cigarette Smoke-Induced COPD in C57BL/6 mice.
PLoS One
May 2016
Article Synopsis
- Cigarette smoke causes chronic obstructive pulmonary disease (COPD), which is a serious health issue with significant economic and social impacts, highlighting the need for new treatment options.
- Mesenchymal stromal cells (MSCs) show potential for treating COPD due to their healing properties, and their effectiveness can be enhanced through adjuvant therapies like low-level laser (LLL) therapy, which is safe and affordable.
- Research using mice exposed to cigarette smoke demonstrated that combining MSC therapy with LLL irradiation significantly reduces lung inflammation, cellular infiltrates, and tissue damage, suggesting this combination could be an effective approach for treating COPD.
We have recently reported that human fallopian tubes, which are discarded during surgical procedures of women submitted to sterilization or hysterectomies, are a rich source of human fallopian tube mesenchymal stromal cells (htMSCs). It has been previously shown that human mesenchymal stromal cells may be useful in enhancing the speed of bone regeneration. This prompted us to investigate whether htMSCs might be useful for the treatment of osteoporosis or other bone diseases, since they present a pronounced capacity for osteogenic differentiation in vitro.
View Article and Find Full Text PDFBackground: The possibility of using stem cells for regenerative medicine has opened a new field of investigation. The search for sources to obtain multipotent stem cells from discarded tissues or through non-invasive procedures is of great interest. It has been shown that mesenchymal stem cells (MSCs) obtained from umbilical cords, dental pulp and adipose tissue, which are all biological discards, are able to differentiate into muscle, fat, bone and cartilage cell lineages.
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