Publications by authors named "Silvio Calderara"
Background: Disparities in type 2 diabetes (T2D) care provision and clinical outcomes have been reported in the last 2 decades in the UK. Since then, a number of initiatives have attempted to address this imbalance. The aim was to evaluate contemporary data as to whether disparities exist in glycaemic control, monitoring, and prescribing in people with T2D.
View Article and Find Full Text PDFIntroduction: Longer medication persistence in type 2 diabetes (T2D) is associated with improved glycaemic control. It is not clear which oral therapies have the best persistence. The objective of this study was to compare medication persistence across different oral therapies in people with T2D.
View Article and Find Full Text PDFSézary syndrome (SzS) is an advanced form of cutaneous T-cell lymphoma characterized by peripheral blood involvement, impaired cell-mediated immunity, and T-helper 1 (TH1) cytokine production. To understand the mechanism of these defects, we studied the expression and function of CD40L in peripheral blood mononuclear cells (PBMCs) of patients with SzS. We found that PBMCs of patients with SzS have a defect in interleukin-12 (IL-12) and tumor necrosis factor-alpha (TNF-alpha) production upon anti-CD3 stimulation and that tumor CD4+ T lymphocytes have a specific defect in CD40L induction after anti-CD3 ligation in vitro.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how different forms of Fas ligand (FasL) induce apoptosis (programmed cell death), with membrane-bound FasL triggering the process while the soluble form does not unless cross-linked.
- Researchers engineered hexameric FasL proteins that showed increased cytotoxicity and successfully induced apoptosis by forming a signaling complex.
- The research uncovered three critical steps in Fas-mediated apoptosis—receptor binding, activation, and recruitment of signaling molecules—highlighting that FasL's oligomerization is essential for effective signaling.