Publications by authors named "Silvina Perin"
The metabolic routes altered in Alzheimer's disease (AD) brain are poorly understood. As the metabolic pathways are evolutionarily conserved, the metabolic profiles carried out in animal models of AD could be directly translated into human studies. We performed untargeted Nuclear Magnetic Resonance metabolomics in hippocampus of McGill-R-Thy1-APP transgenic (Tg) rats, a model of AD-like cerebral amyloidosis and the translational potential of these findings was assessed by targeted Gas Chromatography-Electron Impact-Mass Spectrometry in plasma of participants in the German longitudinal cohort AgeCoDe.
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- * Researchers found that this mouse model exhibited symptoms similar to human patients, identifying vitamin B2 and other compounds as potential biomarkers for diagnosis and monitoring the disease.
- * The study suggested that deficiencies in the CYP2U1 enzyme disrupts mitochondrial function and neurodevelopment but may be mitigated by folate supplementation, highlighting possible avenues for therapeutic intervention.