Publications by authors named "Silvia Torrents-Zapata"
Article Synopsis
- - This study focused on scaling up a small cardiac tissue engineering construct, known as PeriCord, into a human-size therapeutic product to aid post-heart attack recovery in patients.
- - PeriCord is made from a decellularised pericardial matrix and contains human stem cells, with tests confirming its quality and safety before it was implanted in a patient with significant heart damage.
- - The first implantation in a 63-year-old male showed promising results, with no adverse reactions or need for immunosuppression, and a notable reduction in the heart scar observed after three months.
Background Aims: Multipotent mesenchymal stromal cell (MSC)-based medicines are extensively investigated for use in regenerative medicine and immunotherapy applications. The International Society for Cell and Gene Therapy (ISCT) proposed a panel of cell surface molecules for MSC identification that includes human leukocyte antigen (HLA)-DR as a negative marker. However, its expression is largely unpredictable despite production under tightly controlled conditions and compliance with current Good Manufacturing Practices.
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