Publications by authors named "Silvia Spinillo"
Background: Controversial evidence suggests a potential association between female genital mutilation (FGM/C) and adverse obstetric outcomes, with type III FGM/C (infibulation) carrying the greatest risk. The aim of this systematic review and meta-analysis was to assess current rate of adverse obstetric outcomes in women with type III female genital mutilation and cutting (FGM/C; infibulation) delivering across different settings worldwide.
Methods: PubMed, Scopus, Embase, and ClinicalTrials.
Objective: This study aimed to assess the rate of adverse obstetrical and neonatal outcomes in pregnancies diagnosed with confined placental mosaicism relative to that of unaffected controls.
Data Sources: Web-based databases were searched using relevant key words, and articles published from 1980 to February 2022 were retrieved.
Study Eligibility Criteria: Observational studies in English language including ≥10 cases of singleton pregnancies with diagnosis of confined placental mosaicism were included.
Abnormalities of the left brachiocephalic vein (LBCVA) are rare and poorly studied prenatally. An association with congenital heart defects (CHD), extracardiac and genetic abnormalities was described. The aim of our study was to estimate the rate and summarize the available evidence concerning prenatal diagnosis, associated anomalies, and outcomes of these anomalies.
View Article and Find Full Text PDFObjectives: The aim of this study was to describe the radiological features of chronic thromboembolic pulmonary disease (CTEPD), not yet systematically described in the literature. Furthermore, we compared vascular scores between CTEPD and chronic thromboembolic pulmonary hypertension (CTEPH) patients, trying to explain why pulmonary hypertension does not develop at rest in CTEPD patients.
Methods: Eighty-five patients (40 CTEPD, 45 CTEPH) referred to our centre for pulmonary endarterectomy underwent dual-energy computed tomography pulmonary angiography (DE-CTPA) with iodine perfusion maps; other 6 CTEPD patients underwent single-source CTPA.
Objective: To compare first-trimester fetal crown-rump length (CRL) measurements in pregnancies obtained after thawed blastocyst transfer versus fresh blastocyst transfer after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).
Design: Prospective longitudinal cohort study of CRL Z scores with adjustment for major confounders.
Setting: University-affiliated obstetrics, fetal medicine, and fertility units.
Article Synopsis
- Right aortic arch (RAA) occurs in 0.1% of the population and this study assessed the risk of heart and chromosomal abnormalities in fetuses with RAA and a right ductal arch (RDA).
- A meta-analysis of 18 studies found a 30% risk of associated conotruncal congenital heart defects (CHDs) and a 1% risk of 22q11 microdeletion, mainly affecting the thymus.
- The risks for various abnormalities were similar whether RAA occurred with a right or left ductal arch; when conditions are isolated and the thymus and genetic tests are normal, reassurance is advised.