Publications by authors named "Silvia Podavini"
Article Synopsis
- PD1 is a protein on T cells that helps prevent them from attacking cancer, but not all patients benefit from treatments targeting it.
- Scientists studied how PD1 impacts certain proteins in T cells and found it stops a key protein called PKCθ from working properly.
- This blockage may cause smaller immune attacks on cancer, so measuring changes in a related protein, vimentin, could help doctors understand how well the treatment is working.
The caspase-like protease MALT1 promotes immune responses and oncogenesis in mammals by activating the transcription factor NF-κB. MALT1 is remarkably conserved from mammals to simple metazoans devoid of NF-κB homologs, like the nematode . To discover more ancient, NF-κB -independent MALT1 functions, we analysed the phenotype of upon silencing of MALT-1 expression systemically or in a tissue-specific manner.
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- Relapse and graft-versus-host disease (GVHD) are major causes of death after hematopoietic cell transplantation (HCT), and invariant natural killer T (iNKT) cells may help prevent GVHD while fighting malignancies.
- This study aimed to enhance the effectiveness of iNKT cells by creating CD19-CAR-iNKT cells that target lymphoma while maintaining their immune-regulatory properties.
- Results showed that while CD19-CAR-iNKT cells can induce target cell death, they also face exhaustion; however, using checkpoint inhibitors like nivolumab boosted their effectiveness and reduced the risk of GVHD.