BRAF mutational status is associated with survival outcomes in locally advanced resectable and metastatic NSCLC.

Background: Immunotherapy-based treatments have demonstrated high efficacy in patients with advanced and locally advanced non-small-cell lung cancer (NSCLC). BRAF mutations affect a small but significant fraction of NSCLC. The efficacy of these therapies in this subgroup of patients is unknown.

Comparison of four valproic acid free fraction determination methods used in clinical practice.

Objective: Given that hypoalbuminemia tends to result in higher free fraction  concentrations of valproic acid, different methods have been developed to  determine the latter in patients with this condition. The aim of this study is to  assess the reliability of these methods and, if necessary, design a new  estimation method.

Method: A retrospective analysis was carried out by the Pharmacy Department of Severo Ochoa University Hospital of admitted patients with at least one  trough concentration of valproic acid between October 2017 and February  2019.

Assessment of exposure-response relationship for cetuximab in patients with metastatic colorectal cancer and head and neck cancer.

Objective: There is limited scientific evidence on the cetuximab exposure-response relationship and no concentration threshold has been associated with optimal disease control. The aims were to assess, in a real-life setting, the  relationship between steady state cetuximab concentrations (Ctrough, SS) and  disease control.

Method: A prospective observational study in patients with metastatic colorectal cancer or head and neck cancer treated with cetuximab.

Assessment of exposure-response relationship for bevacizumab in patients with metastatic colorectal cancer.

Limited literature is available for bevacizumab exposure-response relationship and there is not a concentration threshold associated with an optimal disease control. This prospective observational study in patients with metastatic colorectal cancer (mCRC) aims to evaluate, in a real-life setting, the relationship between bevacizumab through concentrations at steady state (C) and disease control. C were drawn, coinciding with the radiological evaluation of the response (progression or clinical benefit).

Degree of technological implementation in intravenous chemotherapy management in hospitals of the Autonomous Community of Madrid.

Objective: To understand the degree of technological implementation in the processes of preparation and administration of cytostatics drugs that is available in those hospitals of the Autonomous Community of Madrid where intravenous chemotherapy is prepared.

Method: A descriptive observational study through the completion of a survey targeted to the staff responsible for the preparation of this type of treatments.

Results: The degree of implementation of assisted electronic prescription is high, there is a medium degree in the case of bar code reading technology, and low in terms of vial re-labelling and gravimetric and voice control for preparation.

Population pharmacokinetics of gentamicin and dosing optimization for infants.

The aim of this study was to characterize and validate the population pharmacokinetics of gentamicin in infants and to determine the influences of clinically relevant covariates to explain the inter- and intraindividual variabilities associated with this drug. Infants receiving intravenous gentamicin and with routine therapeutic drug monitoring were consecutively enrolled in the study. Plasma concentration and time data were retrospectively collected from 208 infants (1 to 24 months old) of the Hospital Universitario Severo Ochoa (Spain), of whom 44% were males (mean age [± standard deviation], 5.