Publications by authors named "Silvia Mingoia"
Acyl CoA binding protein encoded by diazepam binding inhibitor (ACBP/DBI) is a tissue hormone that stimulates lipo-anabolic responses and inhibits autophagy, thus contributing to aging and age-related diseases. Protein expression profiling of ACBP/DBI was performed on mouse tissues to identify organs in which this major tissue hormone is expressed. Transcriptomic and proteomic data bases corroborated a high level of human-mouse interspecies conservation of ACBP/DBI expression in different organs.
View Article and Find Full Text PDFArticle Synopsis
- Higher plasma levels of ACBP/DBI, linked to age and obesity, are associated with an increased risk of cancer, especially in patients with genetic predispositions like BRCA1/2 or TP53 mutations.
- In studies, elevated ACBP/DBI levels were predictive of future cancer development, particularly lung cancer, while neutralization of ACBP/DBI slowed tumor growth and enhanced the effects of chemoimmunotherapy in animal models.
- The research suggests that ACBP/DBI functions as an immune suppressor and indicates that targeting it may improve cancer immunotherapy outcomes.