Association between nutrient intake related to the one-carbon metabolism and colorectal cancer risk: a case-control study in the Basque Country.

Purpose: Epidemiologic evidence for the association between methyl-donor nutrient intake and colorectal cancer (CRC) risk remains inconclusive. We aimed to examine the relationship between intake of vitamins of the B group, methionine, total choline and betaine and CRC risk, in a population from the CRC screening programme in the Basque Country.

Design: This observational study included 308 patients with CRC and 308 age- and sex-matched subjects as controls.

Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer: A systematic review of observational studies.

Background: Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). However, whether the influence of methyl donor intake is modified by polymorphisms in such epigenetic regulators is still unclear.

Aim: To improve the current understanding of the molecular basis of CRC

Methods: A literature search in the Medline database, (https:// www.