Publications by authors named "Silvia Marsicano"
Article Synopsis
- Mutations in the LRRK2 gene are linked to familial Parkinson's disease, with the protein having important interaction domains at both its ends.
- This study used microscopy and assays to find that the N- and C-terminal domains of LRRK2 affect synaptic vesicle movement in opposing ways and bind to different proteins.
- The G2385R variant in the C-terminal domain increases Parkinson's risk by altering protein interactions and synaptic vesicle fusion, potentially leading to impaired vesicular trafficking and disease progression.
